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HomoloGene:55718. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

STAT5B,  H.sapiens
signal transducer and activator of transcription 5B
NP_036580.2
787 aa
STAT5B,  P.troglodytes
signal transducer and activator of transcription 5B
XP_001166251.1
782 aa
STAT5B,  M.mulatta
signal transducer and activator of transcription 5B
XP_001109317.2
718 aa
STAT5B,  C.lupus
signal transducer and activator of transcription 5B
XP_548092.1
787 aa
STAT5B,  B.taurus
signal transducer and activator of transcription 5B
NP_777042.2
787 aa
Stat5b,  M.musculus
signal transducer and activator of transcription 5B
NP_035619.3
786 aa
Stat5b,  R.norvegicus
signal transducer and activator of transcription 5B
NP_071775.1
786 aa
STAT5B,  G.gallus
signal transducer and activator of transcription 5B
NP_990110.1
787 aa
stat5b,  X.tropicalis
signal transducer and activator of transcription 5B
XP_002943467.1
781 aa
stat5.2,  D.rerio
signal transducer and activator of transcription 5.2
NP_001003984.1
787 aa
stat5.1,  D.rerio
signal transducer and activator of transcription 5.1
NP_919368.1
785 aa
sta-1,  C.elegans
sta-1
NP_502974.2
706 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Growth hormone insensitivity with immunodeficiency.
Leukemia, acute promyelocytic, STAT5B/RARA type.



Publications
Articles associated with genes and sequences of this homology group.

The Jak/STAT signaling pathway is downregulated at febrile temperatures.
Nespital T & Strous GJ. PLoS One 7, e49374 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
STAT_bind (pfam02864)
  STAT protein, DNA binding domain.
STAT_alpha (pfam01017)
  STAT protein, all-alpha domain.
STAT_int (pfam02865)
  STAT protein, protein interaction domain.
SH2 (cl15255)
  Src homology 2 (SH2) domain.
STAT_alpha (pfam01017)
  STAT protein, all-alpha domain.
STAT_int (cl03749)
  STAT protein, protein interaction domain.
SH2 (cl15255)
  Src homology 2 (SH2) domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Stat5b includes H.sapiens STAT5B and R.norvegicus Stat5b.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (15 transcripts, 10 species)
Mammalia - mammals (14 transcripts, 11 species)
Ascidiacea - tunicates (2 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 1 species)
Amniota - vertebrates (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (2 transcripts, 2 species)
Arachnida - arachnids (1 transcript, 1 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Malacostraca - crustaceans (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (3 transcripts, 2 species)

Nematoda
Chromadorea - nematodes (3 transcripts, 2 species)

Echinodermata
Echinoidea - sea urchins (3 transcripts, 2 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

 

 

 

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