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HomoloGene

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HomoloGene:1531. Gene conserved in Bilateria

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Genes Genes identified as putative homologs of one another during the construction of HomoloGene.			Proteins Proteins used in sequence comparisons and their conserved domain architectures.
	FMR1, H.sapiens fragile X mental retardation 1			NP_002015.1 632 aa
	FMR1, P.troglodytes fragile X mental retardation 1			XP_521294.3 632 aa
	FMR1, M.mulatta fragile X mental retardation 1			XP_001087617.2 718 aa
	FMR1, C.lupus fragile X mental retardation 1			XP_866618.1 632 aa
	FMR1, B.taurus fragile X mental retardation 1			NP_001179079.1 632 aa
	Fmr1, M.musculus fragile X mental retardation syndrome 1			NP_032057.2 614 aa
	Fmr1, R.norvegicus fragile X mental retardation 1			NP_434691.1 581 aa
	FMR1, G.gallus fragile X mental retardation 1			XP_420363.1 565 aa
	fmr1, X.tropicalis fragile X mental retardation 1			NP_001005454.1 590 aa
	fmr1, D.rerio fragile X mental retardation 1			NP_694495.1 569 aa
	Fmr1, D.melanogaster Fmr1			NP_731444.1 681 aa

Protein Alignments

Protein multiple alignment, pairwise similarity scores and evolutionary distances.

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Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST

Regenerate Alignments

Phenotypes Phenotypic information for the genes in this entry imported from model organism databases.
*H.sapiens*
MIM:300623 Fragile X tremor/ataxia syndrome.
MIM:300624 Fragile X syndrome.

Publications Articles associated with genes and sequences of this homology group.
The developmental switch in GABA polarity is delayed in fragile X mice. He Q, et al. J Neurosci 34, 446-50 (2014).
Loss of functional A-type potassium channels in the dendrites of CA1 pyramidal neurons from a mouse model of fragile X syndrome. Routh BN, et al. J Neurosci 33, 19442-50 (2013).
The DNA replication program is altered at the FMR1 locus in fragile X embryonic stem cells. Gerhardt J, et al. Mol Cell 53, 19-31 (2014).
Biophysical characterization of G-quadruplex forming FMR1 mRNA and of its interactions with different fragile X mental retardation protein isoforms. Blice-Baum AC & Mihailescu MR. RNA 20, 103-14 (2014).
The roles of FMRP-regulated genes in autism spectrum disorder: single- and multiple-hit genetic etiologies. Steinberg J & Webber C. Am J Hum Genet 93, 825-39 (2013).
Nuclear Fragile X Mental Retardation Protein is localized to Cajal bodies. Dury AY, et al. PLoS Genet 9, e1003890 (2013).
Impaired critical period plasticity in primary auditory cortex of fragile X model mice. Kim H, et al. J Neurosci 33, 15686-92 (2013).
Programmed cell death is impaired in the developing brain of FMR1 mutants. Cheng Y, et al. Dev Neurosci 35, 347-58 (2013).
Cognitive-motor interference during postural control indicates at-risk cerebellar profiles in females with the FMR1 premutation. Kraan CM, et al. Behav Brain Res 253, 329-36 (2013).
Advances in clinical and molecular understanding of the FMR1 premutation and fragile X-associated tremor/ataxia syndrome. Hagerman R & Hagerman P. Lancet Neurol 12, 786-98 (2013).
See all (694)

Conserved Domains Conserved Domains from CDD found in protein sequences by rpsblast searching.
Agenet (smart00743) Tudor-like domain present in plant sequences.
KH_1 (pfam00013) KH domain.
Agenet (pfam05641) Agenet domain.
FXR1P_C (pfam12235) Fragile X-related 1 protein C terminal.
Agenet (pfam05641) Agenet domain.
FXR1P_C (pfam12235) Fragile X-related 1 protein C terminal.
RAM (pfam15320) mRNA cap methylation, RNMT-activating mini protein.
KH-I (cl17245) K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

Related Homology Resources Links to curated and computed homology information found in other databases.
MGI:95564 Orthology group for M.musculus Fmr1 includes H.sapiens FMR1 and R.norvegicus Fmr1.

UniGene Links to UniGene entries found by comparing the homologous proteins against the transcript database.
*Chordata*
Mammalia - mammals (12 transcripts, 12 species)
Actinopterygii - bony fishes (12 transcripts, 7 species)
Amphibia - amphibians (3 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Hyperoartia - vertebrates (1 transcript, 1 species)
*Arthropoda*
Insecta - insects (2 transcripts, 1 species)
*Cnidaria*
Hydrozoa - hydrozoans (1 transcript, 1 species)
*Annelida*
Polychaeta - segmented worms (1 transcript, 1 species)

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