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HomoloGene:68226. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

GSPT1,  H.sapiens
G1 to S phase transition 1
NP_001123478.1
636 aa
GSPT1,  P.troglodytes
G1 to S phase transition 1
XP_001140542.3
346 aa
LOC716860,  M.mulatta
eukaryotic peptide chain release factor GTP-binding subunit ERF3B-like
XP_001107851.2
870 aa
GSPT1,  C.lupus
G1 to S phase transition 1
XP_005621589.1
498 aa
GSPT1,  B.taurus
G1 to S phase transition 1
NP_001091540.2
636 aa
Gspt1,  M.musculus
G1 to S phase transition 1
NP_001123480.1
635 aa
Gspt1,  R.norvegicus
G1 to S phase transition 1
NP_001003978.1
636 aa
LOC100911685,  R.norvegicus
eukaryotic peptide chain release factor GTP-binding subunit ERF3B-like
XP_006245802.1
636 aa
GSPT1,  G.gallus
G1 to S phase transition 1
NP_001129149.1
618 aa
gspt1,  X.tropicalis
G1 to S phase transition 1
NP_001015805.2
573 aa
gspt1l,  D.rerio
G1 to S phase transition 1, like
NP_942101.1
577 aa
gspt1,  D.rerio
G1 to S phase transition 1
NP_001003992.1
564 aa
Elf,  D.melanogaster
Ef1alpha-like factor
NP_001260415.1
619 aa
AgaP_AGAP009310,  A.gambiae
AgaP_AGAP009310
XP_320105.3
478 aa
SUP35,  S.cerevisiae
SUP35
NP_010457.3
685 aa
KLLA0D17424g,  K.lactis
KLLA0D17424g
XP_453831.1
700 aa
AGOS_AGL145W,  E.gossypii
AGOS_AGL145W
NP_986522.2
691 aa
sup35,  S.pombe
sup35
NP_588225.1
662 aa
MGG_00449,  M.oryzae
MGG_00449
XP_003718618.1
731 aa
NCU04790,  N.crassa
NCU04790
XP_960416.1
730 aa
AT1G18070,  A.thaliana
AT1G18070
NP_001185026.1
543 aa
Os04g0270100,  O.sativa
Os04g0270100
NP_001052341.1
444 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Ion-specific effects on prion nucleation and strain formation.
Rubin J, et al. J Biol Chem 288, 30300-8 (2013).
The [PSI+] prion exists as a dynamic cloud of variants.
Bateman DA & Wickner RB. PLoS Genet 9, e1003257 (2013).
[PSI(+) ] prion variant establishment in yeast.
Sharma J & Liebman SW. Mol Microbiol 86, 866-81 (2012).
Effect of electrostatics on aggregation of prion protein Sup35 peptide.
Portillo AM, et al. J Phys Condens Matter 24, 164205 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PAM2 (pfam07145)
  Ataxin-2 C-terminal region.
BASP1 (pfam05466)
  Brain acid soluble protein 1 (BASP1 protein).
PAM2 (pfam07145)
  Ataxin-2 C-terminal region.
DUF1720 (pfam08226)
  Domain of unknown function (DUF1720).
Translation_factor_III (cl02786)
  Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G. Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu ...
Translation_Factor_II_like (cl02787)
  Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to ...
Ras_like_GTPase (cl17170)
  Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases).



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Gspt1 includes H.sapiens GSPT1 and R.norvegicus Gspt1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (29 transcripts, 10 species)
Mammalia - mammals (26 transcripts, 15 species)
Amphibia - amphibians (5 transcripts, 2 species)
Ascidiacea - tunicates (3 transcripts, 3 species)
Amniota - vertebrates (2 transcripts, 1 species)
Aves - birds (2 transcripts, 2 species)
Cephalochordata - lancelets (1 transcript, 1 species)
Hyperoartia - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (13 transcripts, 12 species)
Branchiopoda - crustaceans (2 transcripts, 1 species)
Arachnida - arachnids (1 transcript, 1 species)
Malacostraca - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (3 transcripts, 2 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 2 species)
Turbellaria - flatworms (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (49 transcripts, 31 species)
Liliopsida - monocots (15 transcripts, 9 species)
Coniferopsida - conifers (3 transcripts, 3 species)
Isoetopsida - club-mosses (2 transcripts, 1 species)
Bryopsida - mosses (1 transcript, 1 species)

Chlorophyta
Chlorophyceae - green algae (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (3 transcripts, 3 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (1 transcript, 1 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)
Pythiales - oomycetes (1 transcript, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (1 transcript, 1 species)

Apicomplexa
Coccidia - apicomplexans (1 transcript, 1 species)

Ciliophora
Oligohymenophorea - ciliates (1 transcript, 1 species)

Dictyosteliida
Dictyostelium - cellular slime molds (1 transcript, 1 species)

Codonosigidae
Monosiga - choanoflagellates (1 transcript, 1 species)

 

 

 

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