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HomoloGene:429. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

FGG,  H.sapiens
fibrinogen gamma chain
453 aa
FGG,  P.troglodytes
fibrinogen gamma chain
437 aa
FGG,  M.mulatta
fibrinogen gamma chain
453 aa
FGG,  C.lupus
fibrinogen gamma chain
445 aa
FGG,  B.taurus
fibrinogen gamma chain
444 aa
Fgg,  M.musculus
fibrinogen gamma chain
436 aa
Fgg,  R.norvegicus
fibrinogen gamma chain
437 aa
FGG,  G.gallus
fibrinogen gamma chain
435 aa
fgg,  X.tropicalis
fibrinogen gamma chain
438 aa
fgg,  D.rerio
fibrinogen, gamma polypeptide
431 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

Dysfibrinogenemia, gamma type.
Hypofibrinogenemia, gamma type.
Thrombophilia, dysfibrinogenemic.

Articles associated with genes and sequences of this homology group.

Zn2+ mediates high affinity binding of heparin to the αC domain of fibrinogen.
Fredenburgh JC, et al. J Biol Chem 288, 29394-402 (2013).
Mechanism of fibrin(ogen) forced unfolding.
Zhmurov A, et al. Structure 19, 1615-24 (2011).
Association between γ' fibrinogen levels and inflammation.
Alexander KS, et al. Thromb Haemost 105, 605-9 (2011).
γ'/total fibrinogen ratio is associated with short-term outcome in ischaemic stroke.
van den Herik EG, et al. Thromb Haemost 105, 430-4 (2011).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Fib_alpha (pfam08702)
  Fibrinogen alpha/beta chain family.
FReD (cl00085)
  Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Fgg includes H.sapiens FGG and R.norvegicus Fgg.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (21 transcripts, 14 species)
Actinopterygii - bony fishes (14 transcripts, 11 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)
Hyperoartia - vertebrates (1 transcript, 1 species)




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