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HomoloGene:15856. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

CBLB,  H.sapiens
Cbl proto-oncogene B, E3 ubiquitin protein ligase
982 aa
CBLB,  P.troglodytes
Cbl proto-oncogene, E3 ubiquitin protein ligase B
982 aa
LOC703879,  M.mulatta
e3 ubiquitin-protein ligase CBL-B-like
982 aa
CBLB,  C.lupus
Cbl proto-oncogene B, E3 ubiquitin protein ligase
983 aa
CBLB,  B.taurus
Cas-Br-M (murine) ecotropic retroviral transforming sequence b
983 aa
Cblb,  M.musculus
Casitas B-lineage lymphoma b
938 aa
Cblb,  R.norvegicus
Cbl proto-oncogene B, E3 ubiquitin protein ligase
938 aa
CBLB,  G.gallus
Cbl proto-oncogene, E3 ubiquitin protein ligase B
1025 aa
cblb,  X.tropicalis
Cbl proto-oncogene B, E3 ubiquitin protein ligase
982 aa
cblb,  D.rerio
Cas-Br-M (murine) ecotropic retroviral transforming sequence b
939 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

The role of the e3 ligase cbl-B in murine dendritic cells.
Wallner S, et al. PLoS One 8, e65178 (2013).
Cbl-b regulates airway mucosal tolerance to aeroallergen.
Oh SY, et al. Clin Exp Allergy 41, 434-42 (2011).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Cbl_N (pfam02262)
  CBL proto-oncogene N-terminal domain 1.
Cbl_N2 (pfam02761)
  CBL proto-oncogene N-terminus, EF hand-like domain.
UBA (cl00153)
  Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been suggested that UBA domains are involved in conferring protein target specificity. The domain, a compact three helix bundle, has a conserved GFP-loop and the proline is thought to be critical for binding. The UBA domain is distinct from the conserved three helical domain seen in the N-terminus of EF-TS and eukaryotic NAC proteins.
SH2 (cl15255)
  Src homology 2 (SH2) domain.
RING (cl17238)
  RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Cblb includes H.sapiens CBLB and R.norvegicus Cblb.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (14 transcripts, 11 species)
Actinopterygii - bony fishes (3 transcripts, 3 species)
Amphibia - amphibians (3 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)




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