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HomoloGene:25007. Gene conserved in Bilateria Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

erbb3a,  D.rerio
v-erb-b2 erythroblastic leukemia viral oncogene homolog 3a
1305 aa
erbb3b,  D.rerio
v-erb-b2 erythroblastic leukemia viral oncogene homolog 3b
1429 aa
Egfr,  D.melanogaster
Epidermal growth factor receptor
1377 aa
EGFR,  A.gambiae
1429 aa
let-23,  C.elegans
1262 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

Encodes the Drosophila homolog of epidermal growth factor receptor protein. Mutations with three different phenotypes and described under three different names shown to be alleles of Egfr. Elp (Ellipse) is a dominant eye shape and texture mutant; flb (faint little ball) is an embryonic lethal causing dorsalized embryos, and top (torpedo) is a maternal-effect lethal causing ventralized embryos. Ellipse alleles are dominant (hypermorphic) mutations of Egfr. EgfrE1 in heterozygous combination with a deficiency or null mutation for Egfr is normal in phenotype. (See FlyBase for complete description.)

Articles associated with genes and sequences of this homology group.

Nucleotide variation in the Egfr locus of Drosophila melanogaster.
Palsson A, et al. Genetics 167, 1199-212 (2004).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
TyrKc (smart00219)
  Tyrosine kinase, catalytic domain.
TM_EGFR-like (cl17045)
  Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases.
Recep_L_domain (pfam01030)
  Receptor L domain.
FU (cl00066)
  Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
Recep_L_domain (pfam01030)
  Receptor L domain.
GF_recep_IV (pfam14843)
  Growth factor receptor domain IV.
PKc_like (cl09925)
  Protein Kinases, catalytic domain.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Insecta - insects (7 transcripts, 6 species)
Arachnida - arachnids (1 transcript, 1 species)
Branchiopoda - crustaceans (1 transcript, 1 species)

Chromadorea - nematodes (1 transcript, 1 species)




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