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HomoloGene:1718. Gene conserved in Tetrapoda Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

AFF3,  H.sapiens
AF4/FMR2 family, member 3
NP_001020279.1
1251 aa
AFF3,  P.troglodytes
AF4/FMR2 family, member 3
XP_001160964.2
1380 aa
LOC714408,  M.mulatta
AF4/FMR2 family member 3-like
XP_002808094.1
1839 aa
AFF3,  C.lupus
AF4/FMR2 family, member 3
XP_005626071.1
1249 aa
AFF3,  B.taurus
AF4/FMR2 family, member 3
XP_002691193.1
1227 aa
Aff3,  M.musculus
AF4/FMR2 family, member 3
NP_034808.2
1228 aa
Aff3,  R.norvegicus
AF4/FMR2 family, member 3
NP_001178816.1
1225 aa
AFF3,  G.gallus
AF4/FMR2 family, member 3
XP_004938558.1
1270 aa
aff3,  X.tropicalis
AF4/FMR2 family, member 3
XP_002937914.2
960 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

LAF-4 is aberrantly expressed in human breast cancer.
To MD, et al. Int J Cancer 115, 568-74 (2005).
LAF4, an AF4-related gene, is fused to MLL in infant acute lymphoblastic leukemia.
von Bergh AR, et al. Genes Chromosomes Cancer 35, 92-6 (2002).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
AF-4 (pfam05110)
  AF-4 proto-oncoprotein.
AF-4 (pfam05110)
  AF-4 proto-oncoprotein.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Aff3 includes H.sapiens AFF3 and R.norvegicus Aff3.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (14 transcripts, 7 species)
Actinopterygii - bony fishes (2 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

 

 

 

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