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HomoloGene:41048. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

GIGYF2,  H.sapiens
GRB10 interacting GYF protein 2
NP_001096616.1
1299 aa
GIGYF2,  P.troglodytes
GRB10 interacting GYF protein 2
XP_001148316.1
1301 aa
GIGYF2,  M.mulatta
GRB10 interacting GYF protein 2
XP_001114252.2
1296 aa
GIGYF2,  C.lupus
GRB10 interacting GYF protein 2
XP_861928.1
1290 aa
GIGYF2,  B.taurus
GRB10 interacting GYF protein 2
NP_001095347.1
1291 aa
Gigyf2,  M.musculus
GRB10 interacting GYF protein 2
NP_666224.3
1291 aa
Gigyf2,  R.norvegicus
GRB10 interacting GYF protein 2
XP_006245571.1
1291 aa
GIGYF2,  G.gallus
GRB10 interacting GYF protein 2
NP_001239057.1
1278 aa
gigyf2,  X.tropicalis
GRB10 interacting GYF protein 2
XP_002933400.2
1309 aa
gigfy2,  D.rerio
GRB10 interacting GYF protein 2
NP_001025332.1
1335 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Parkinson disease 11.



Publications
Articles associated with genes and sequences of this homology group.

Follow-up study of the GIGYF2 gene in French families with Parkinson's disease.
Lesage S, et al. Neurobiol Aging 31, 1069-71; discussion 1072-4 (2010).
Summary of GIGYF2 studies in Parkinson's disease: the burden of proof.
Tan EK & Schapira AH. Eur J Neurol 17, 175-6 (2010).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
GYF (cl00072)
  GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Gigyf2 includes H.sapiens GIGYF2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (26 transcripts, 13 species)
Actinopterygii - bony fishes (9 transcripts, 8 species)
Amphibia - amphibians (3 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)
Hyperoartia - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (7 transcripts, 6 species)
Arachnida - arachnids (1 transcript, 1 species)
Branchiopoda - crustaceans (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (3 transcripts, 2 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (1 transcript, 1 species)

 

 

 

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