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HomoloGene:32204. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

GIT1,  H.sapiens
G protein-coupled receptor kinase interacting ArfGAP 1
NP_001078923.1
770 aa
GIT1,  P.troglodytes
G protein-coupled receptor kinase interacting ArfGAP 1
XP_511377.3
770 aa
GIT1,  M.mulatta
G protein-coupled receptor kinase interacting ArfGAP 1
XP_001108023.2
683 aa
GIT1,  C.lupus
G protein-coupled receptor kinase interacting ArfGAP 1
XP_005625057.1
791 aa
GIT1,  B.taurus
G protein-coupled receptor kinase interacting ArfGAP 1
XP_002695750.3
773 aa
Git1,  M.musculus
G protein-coupled receptor kinase-interactor 1
NP_001004144.1
770 aa
Git1,  R.norvegicus
G protein-coupled receptor kinase interacting ArfGAP 1
NP_114002.1
770 aa
GIT1,  G.gallus
G protein-coupled receptor kinase interactor 1
NP_989627.1
740 aa
LOC568935,  D.rerio
ARF GTPase-activating protein GIT1-like
XP_697386.4
761 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Impaired fear response in mice lacking GIT1.
Schmalzigaug R, et al. Neurosci Lett 458, 79-83 (2009).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
GIT1_C (pfam12205)
  G protein-coupled receptor kinase-interacting protein 1 C term.
Shugoshin_N (pfam07558)
  Shugoshin N-terminal coiled-coil region.
GIT_SHD (cl11983)
  Spa2 homology domain (SHD) of GIT.
ANK (cd00204)
  ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
ArfGap (cl02464)
  Putative GTPase activating protein for Arf.
B_zip1 (cl02576)
  basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins.
ArfGap (cl02464)
  Putative GTPase activating protein for Arf.
B_zip1 (cl02576)
  basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Git1 includes H.sapiens GIT1 and R.norvegicus Git1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (12 transcripts, 9 species)
Actinopterygii - bony fishes (2 transcripts, 1 species)
Aves - birds (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Arthropoda
Arachnida - arachnids (1 transcript, 1 species)

 

 

 

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