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HomoloGene:68298. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

SOX2,  H.sapiens
SRY (sex determining region Y)-box 2
NP_003097.1
317 aa
SOX2,  P.troglodytes
SRY (sex determining region Y)-box 2
XP_516895.3
319 aa
SOX2,  M.mulatta
SRY (sex determining region Y)-box 2
NP_001136412.1
319 aa
SOX2,  C.lupus
SRY (sex determining region Y)-box 2
XP_005639809.1
324 aa
SOX2,  B.taurus
SRY (sex determining region Y)-box 2
NP_001098933.1
320 aa
Sox2,  M.musculus
SRY (sex determining region Y)-box 2
NP_035573.3
319 aa
Sox2,  R.norvegicus
SRY (sex determining region Y)-box 2
NP_001102651.1
319 aa
SOX2,  G.gallus
SRY (sex determining region Y)-box 2
NP_990519.1
315 aa
sox2,  X.tropicalis
SRY (sex determining region Y)-box 2
NP_998869.1
311 aa
sox2,  D.rerio
SRY-box containing gene 2
NP_998283.1
315 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Microphthalmia, syndromic 3.
Optic nerve hypoplasia and abnormalities of the central nervous system.



Publications
Articles associated with genes and sequences of this homology group.

Isolation and characterization of human breast cancer cells with SOX2 promoter activity.
Liang S, et al. Biochem Biophys Res Commun 437, 205-11 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
SOXp (pfam12336)
  SOX transcription factor.
HMG-box (cl00082)
  High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Sox2 includes H.sapiens SOX2 and R.norvegicus Sox2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (10 transcripts, 9 species)
Actinopterygii - bony fishes (8 transcripts, 7 species)
Amphibia - amphibians (2 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (2 transcripts, 2 species)
Arachnida - arachnids (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 2 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)

 

 

 

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