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HomoloGene:37507. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

AQP4,  H.sapiens
aquaporin 4
NP_001641.1
323 aa
AQP4,  P.troglodytes
aquaporin 4
XP_512074.2
323 aa
AQP4,  M.mulatta
aquaporin 4
XP_001097418.1
323 aa
AQP4,  C.lupus
aquaporin 4
XP_855456.2
323 aa
AQP4,  B.taurus
aquaporin 4
NP_851346.1
323 aa
Aqp4,  M.musculus
aquaporin 4
NP_033830.2
323 aa
Aqp4,  R.norvegicus
aquaporin 4
NP_036957.1
323 aa
AQP4,  G.gallus
aquaporin 4
NP_001004765.1
335 aa
aqp4,  X.tropicalis
aquaporin 4
XP_002940974.2
318 aa
aqp4,  D.rerio
aquaporin 4
NP_001003749.1
320 aa
Drip,  D.melanogaster
Drip
NP_001260893.1
278 aa
AQP_ANOGA,  A.gambiae
AQP_ANOGA
XP_319584.4
250 aa
PIP1C,  A.thaliana
PIP1C
NP_171668.1
286 aa
PIP1A,  A.thaliana
PIP1A
NP_001078323.1
286 aa
PIP1;4,  A.thaliana
PIP1;4
NP_567178.1
287 aa
PIP1B,  A.thaliana
PIP1B
NP_182120.1
286 aa
PIP1;5,  A.thaliana
PIP1;5
NP_194071.1
287 aa
Os02g0666200,  O.sativa
Os02g0666200
NP_001047672.1
289 aa
Os02g0823100,  O.sativa
Os02g0823100
NP_001048566.1
288 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Neuromyelitis optica IgG causes placental inflammation and fetal death.
Saadoun S, et al. J Immunol 191, 2999-3005 (2013).
Reactivity to AQP4 epitopes in relapsing-remitting multiple sclerosis.
Alexopoulos H, et al. J Neuroimmunol 260, 117-20 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
MIP (cl00200)
  Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Aqp4 includes H.sapiens AQP4 and R.norvegicus Aqp4.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Streptophyta
Eudicotyledons - eudicots (63 transcripts, 32 species)
Coniferopsida - conifers (30 transcripts, 3 species)
Liliopsida - monocots (12 transcripts, 4 species)
Isoetopsida - club-mosses (2 transcripts, 1 species)

Chordata
Mammalia - mammals (13 transcripts, 11 species)
Actinopterygii - bony fishes (3 transcripts, 3 species)
Amphibia - amphibians (2 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (14 transcripts, 11 species)
Malacostraca - crustaceans (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (5 transcripts, 2 species)

Annelida
Polychaeta - segmented worms (2 transcripts, 1 species)
Hirudinida - segmented worms (2 transcripts, 1 species)

Cnidaria
Hydrozoa - hydrozoans (2 transcripts, 1 species)

Codonosigidae
Monosiga - choanoflagellates (3 transcripts, 1 species)

 

 

 

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