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HomoloGene:460. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

TP53,  H.sapiens
tumor protein p53
NP_000537.3
393 aa
TP53,  P.troglodytes
tumor protein p53
XP_001172077.2
393 aa
TP53,  M.mulatta
tumor protein p53
NP_001040616.1
393 aa
TP53,  C.lupus
tumor protein p53
NP_001003210.1
381 aa
TP53,  B.taurus
tumor protein p53
NP_776626.1
386 aa
Trp53,  M.musculus
transformation related protein 53
NP_035770.2
390 aa
Tp53,  R.norvegicus
tumor protein p53
NP_112251.2
391 aa
tp53,  X.tropicalis
tumor protein p53
NP_001001903.1
362 aa
tp53,  D.rerio
tumor protein p53
NP_001258749.1
374 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Breast cancer.
Colorectal cancer.
Hepatocellular carcinoma.
Li-Fraumeni syndrome.
Nasopharyngeal carcinoma.
Histiocytoma.
Multiple malignancy syndrome.
Osteosarcoma.
Thyroid carcinoma.
Adrenal cortical carcinoma.
Pancreatic cancer.



Publications
Articles associated with genes and sequences of this homology group.




Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
P53_tetramer (pfam07710)
  P53 tetramerisation motif.
P53_TAD (pfam08563)
  P53 transactivation motif.
P53 (cl14608)
  P53 DNA-binding domain.
P53_tetramer (pfam07710)
  P53 tetramerization motif.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Trp53 includes H.sapiens TP53 and R.norvegicus Tp53.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (18 transcripts, 15 species)
Actinopterygii - bony fishes (10 transcripts, 8 species)
Amphibia - amphibians (2 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)

 

 

 

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