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HomoloGene:7845. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

MPL,  H.sapiens
myeloproliferative leukemia virus oncogene
NP_005364.1
635 aa
MPL,  M.mulatta
myeloproliferative leukemia virus oncogene
XP_002801551.1
636 aa
MPL,  B.taurus
myeloproliferative leukemia virus oncogene
NP_001179592.1
644 aa
Mpl,  M.musculus
myeloproliferative leukemia virus oncogene
NP_001116421.1
633 aa
Mpl,  R.norvegicus
myeloproliferative leukemia virus oncogene
XP_345573.5
644 aa
MPL,  G.gallus
myeloproliferative leukemia virus oncogene
NP_001001782.1
630 aa
mpl,  D.rerio
myeloproliferative leukemia virus oncogene
NP_001003858.1
614 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Thrombycytosis, susceptibility to.
Thrombocytopenia, congenital amegakaryocytic.



Publications
Articles associated with genes and sequences of this homology group.

MPL Baltimore mutation and thrombocytosis: case report and literature review.
Shkalim-Zemer V, et al. J Pediatr Hematol Oncol 35, e112-4 (2013).
MPL W515L mutation in pediatric essential thrombocythemia.
Farruggia P, et al. Pediatr Blood Cancer 60, E52-4 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
EpoR_lig-bind (pfam09067)
  Erythropoietin receptor, ligand binding.
EpoR_lig-bind (pfam09067)
  Erythropoietin receptor, ligand binding.
FN3 (cl00065)
  Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Mpl includes H.sapiens MPL and R.norvegicus Mpl.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (7 transcripts, 7 species)
Actinopterygii - bony fishes (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

 

 

 

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