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HomoloGene:74382. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

ACACB,  H.sapiens
acetyl-CoA carboxylase beta
NP_001084.3
2458 aa
ACACB,  P.troglodytes
acetyl-CoA carboxylase beta
XP_003313981.1
2458 aa
ACACB,  M.mulatta
acetyl-CoA carboxylase beta
XP_002798817.1
2258 aa
ACACB,  C.lupus
acetyl-CoA carboxylase beta
XP_005636385.1
2431 aa
ACACB,  B.taurus
acetyl-CoA carboxylase beta
NP_001192262.1
2431 aa
Acacb,  M.musculus
acetyl-Coenzyme A carboxylase beta
NP_598665.2
2448 aa
Acacb,  R.norvegicus
acetyl-CoA carboxylase beta
NP_446374.1
2456 aa
ACACB,  G.gallus
acetyl-CoA carboxylase beta
XP_428114.4
2370 aa
acacb,  X.tropicalis
acetyl-CoA carboxylase beta
NP_001131086.1
2387 aa
acacb,  D.rerio
acetyl-CoA carboxylase beta
XP_005165251.1
2378 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Phenotypic discrepancies in acetyl-CoA carboxylase 2-deficient mice.
Hoehn KL, et al. J Biol Chem 287, 15801; author reply 15802 (2012).
Association of ACACB polymorphisms with obesity and diabetes.
Riancho JA, et al. Mol Genet Metab 104, 670-6 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
CPSase_L_chain (pfam00289)
  Carbamoyl-phosphate synthase L chain, N-terminal domain.
Carboxyl_trans (pfam01039)
  Carboxyl transferase domain.
ACC_central (pfam08326)
  Acetyl-CoA carboxylase, central region.
AccB (COG0511)
  Biotin carboxyl carrier protein [Lipid metabolism].
ATP-grasp_4 (cl17255)
  ATP-grasp domain.
PRK07189 (cl17682)
  malonate decarboxylase subunit beta; Reviewed.
CPSase_L_chain (pfam00289)
  Carbamoyl-phosphate synthase L chain, N-terminal domain.
Carboxyl_trans (pfam01039)
  Carboxyl transferase domain.
ACC_central (pfam08326)
  Acetyl-CoA carboxylase, central region.
Biotin_carb_C (cl08365)
  Biotin carboxylase C-terminal domain.
Biotinyl_lipoyl_domains (cl11404)
  Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl, ...
ATP-grasp_4 (cl17255)
  ATP-grasp domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Acacb includes H.sapiens ACACB and R.norvegicus Acacb.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (13 transcripts, 9 species)
Actinopterygii - bony fishes (11 transcripts, 7 species)
Amphibia - amphibians (2 transcripts, 2 species)

Arthropoda
Insecta - insects (1 transcript, 1 species)
Arachnida - arachnids (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (3 transcripts, 1 species)

Oomycetes
Pythiales - oomycetes (2 transcripts, 1 species)

 

 

 

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