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HomoloGene:2408. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

TCF3,  H.sapiens
transcription factor 3
NP_001129611.1
651 aa
TCF3,  P.troglodytes
transcription factor 7-like 1 (T-cell specific, HMG-box)
XP_003954574.1
563 aa
TCF3,  C.lupus
transcription factor 3
XP_542197.3
653 aa
TCF3,  B.taurus
transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)
NP_001179627.1
639 aa
Tcf3,  M.musculus
transcription factor 3
NP_001157619.1
653 aa
Tcf3,  R.norvegicus
transcription factor 3
NP_598208.2
649 aa
TCF3,  G.gallus
transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)
NP_989817.2
669 aa
tcf3,  X.tropicalis
transcription factor 3
NP_001093743.1
655 aa
tcf3b,  D.rerio
transcription factor 3b
NP_001166154.1
652 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Leukemia, acute lymphoblastic.



Publications
Articles associated with genes and sequences of this homology group.

Tcf3 and cell cycle factors contribute to butyrate resistance in colorectal cancer cells.
Chiaro C, et al. Biochem Biophys Res Commun 428, 121-6 (2012).
Genomic loss of the putative tumor suppressor gene E2A in human lymphoma.
Steininger A, et al. J Exp Med 208, 1585-93 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
HLH (cl00081)
  Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Tcf3 includes H.sapiens TCF3 and R.norvegicus Tcfe2a.
Orthology group for M.musculus Tcf7l1 includes H.sapiens TCF7L1 and R.norvegicus Tcf3.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (7 transcripts, 7 species)
Actinopterygii - bony fishes (4 transcripts, 3 species)
Amphibia - amphibians (3 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

 

 

 

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