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HomoloGene:7927. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

SCN8A,  H.sapiens
sodium channel, voltage gated, type VIII, alpha subunit
NP_055006.1
1980 aa
SCN8A,  P.troglodytes
sodium channel, voltage gated, type VIII, alpha subunit
XP_001141985.3
1914 aa
SCN8A,  M.mulatta
sodium channel, voltage gated, type VIII, alpha subunit
XP_001090295.1
1980 aa
SCN8A,  C.lupus
sodium channel, voltage gated, type VIII, alpha subunit
XP_850134.1
1980 aa
SCN8A,  B.taurus
sodium channel, voltage gated, type VIII, alpha subunit
NP_001180031.1
1980 aa
Scn8a,  M.musculus
sodium channel, voltage-gated, type VIII, alpha
NP_001070967.1
1978 aa
Scn8a,  R.norvegicus
sodium channel, voltage gated, type VIII, alpha subunit
NP_062139.2
1978 aa
SCN8A,  G.gallus
sodium channel, voltage gated, type VIII, alpha subunit
XP_003643160.1
1978 aa
LOC101731347,  X.tropicalis
sodium channel protein type 8 subunit alpha-like
XP_004911965.1
1600 aa
scn8ab,  D.rerio
sodium channel, voltage-gated, type VIII, alpha b
NP_001038648.1
1958 aa
scn8aa,  D.rerio
sodium channel, voltage-gated, type VIII, alpha a
NP_571703.1
1949 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Reduced Retinal Function in the Absence of Na(v)1.6.
Smith BJ & Côté PD. PLoS One 7, e31476 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Ion_trans (pfam00520)
  Ion transport protein.
Na_trans_assoc (pfam06512)
  Sodium ion transport-associated.
DUF3451 (pfam11933)
  Domain of unknown function (DUF3451).
Na_channel_gate (cd13433)
  Inactivation gate of the voltage-gated sodium channel alpha subunits.
Ion_trans (pfam00520)
  Ion transport protein.
Na_trans_assoc (pfam06512)
  Sodium ion transport-associated.
DUF3451 (pfam11933)
  Domain of unknown function (DUF3451).
IQ (cl15479)
  Calmodulin-binding motif.
ApoLp-III_like (cl19113)
  Apolipophorin-III and similar insect proteins.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Scn8a includes H.sapiens SCN8A and R.norvegicus Scn8a.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (27 transcripts, 9 species)
Mammalia - mammals (12 transcripts, 8 species)
Amphibia - amphibians (6 transcripts, 1 species)
Aves - birds (3 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Hyperoartia - vertebrates (1 transcript, 1 species)

 

 

 

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