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HomoloGene:3800. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

CAPN1,  H.sapiens
calpain 1, (mu/I) large subunit
NP_001185797.1
714 aa
CAPN1,  P.troglodytes
calpain 1, (mu/I) large subunit
XP_001169100.1
714 aa
CAPN1,  M.mulatta
calpain 1, (mu/I) large subunit
XP_001114172.1
714 aa
CAPN1,  C.lupus
calpain 1, (mu/I) large subunit
XP_540866.2
712 aa
CAPN1,  B.taurus
calpain 1, (mu/I) large subunit
NP_776684.1
716 aa
Capn1,  M.musculus
calpain 1
NP_001103974.1
713 aa
Capn1,  R.norvegicus
calpain 1, (mu/I) large subunit
NP_062025.1
713 aa
CAPN1,  G.gallus
calpain 1, (mu/I) large subunit
NP_001038137.1
715 aa
capn1,  X.tropicalis
calpain 1, (mu/I) large subunit
NP_001013632.1
713 aa
zgc:55262,  D.rerio
zgc:55262
NP_998624.1
704 aa
si:dkeyp-50d11.2,  D.rerio
si:dkeyp-50d11.2
XP_689397.5
679 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Calpain inhibition attenuates apoptosis of retinal ganglion cells in acute optic neuritis.
Smith AW, et al. Invest Ophthalmol Vis Sci 52, 4935-41 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
EF_hand_6 (pfam13833)
  EF-hand domain pair.
EFh (cd00051)
  EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
EF1B (cl00194)
  Elongation factor 1 beta (EF1B) guanine nucleotide exchange domain. EF1B catalyzes the exchange of GDP bound to the G-protein, EF1A, for GTP, an important step in the elongation cycle of the protein biosynthesis. EF1A binds to and delivers the aminoacyl ...
CysPc (cl00051)
  Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
Calpain_III (cl00165)
  Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
EF-hand_8 (cl17302)
  EF-hand domain pair.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Capn1 includes H.sapiens CAPN1 and R.norvegicus Capn1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (14 transcripts, 13 species)
Actinopterygii - bony fishes (8 transcripts, 6 species)
Amphibia - amphibians (3 transcripts, 2 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 2 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

 

 

 

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