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HomoloGene:201. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

KCNH2,  H.sapiens
potassium voltage-gated channel, subfamily H (eag-related), member 2
NP_000229.1
1159 aa
KCNH2,  P.troglodytes
potassium voltage-gated channel, subfamily H (eag-related), member 2
XP_001137384.2
1159 aa
LOC714174,  M.mulatta
potassium voltage-gated channel subfamily H member 2-like
XP_002808416.1
1166 aa
KCNH2,  C.lupus
potassium voltage-gated channel, subfamily H (eag-related), member 2
NP_001003145.1
1158 aa
Kcnh2,  M.musculus
potassium voltage-gated channel, subfamily H (eag-related), member 2
NP_038597.2
1162 aa
Kcnh2,  R.norvegicus
potassium voltage-gated channel, subfamily H (eag-related), member 2
NP_446401.1
1163 aa
LOC100858122,  G.gallus
potassium voltage-gated channel subfamily H member 2-like
XP_003640714.2
985 aa
kcnh2a,  D.rerio
potassium voltage-gated channel, subfamily H (eag-related), member 2a
NP_001036187.1
1253 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Long QT syndrome, acquired, susceptibility to.
Long QT syndrome-2.
Short QT syndrome-1.



Publications
Articles associated with genes and sequences of this homology group.

Chimeric hERG channels containing a tetramerization domain are functional and stable.
Hausammann GJ & Grütter MG. Biochemistry 52, 9237-45 (2013).
Mechanism of hERG channel block by the psychoactive indole alkaloid ibogaine.
Thurner P, et al. J Pharmacol Exp Ther 348, 346-58 (2014).
Electrocardiographic screening of 1-month-old infants for identifying prolonged QT intervals.
Yoshinaga M, et al. Circ Arrhythm Electrophysiol 6, 932-8 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Ion_trans (pfam00520)
  Ion transport protein.
PAS_9 (pfam13426)
  PAS domain.
Ion_trans (pfam00520)
  Ion transport protein.
APC_basic (pfam05956)
  APC basic domain.
PAS_9 (pfam13426)
  PAS domain.
CAP_ED (cl00047)
  effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Kcnh2 includes H.sapiens KCNH2 and R.norvegicus Kcnh2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (13 transcripts, 10 species)
Actinopterygii - bony fishes (4 transcripts, 2 species)
Aves - birds (2 transcripts, 1 species)

Arthropoda
Insecta - insects (3 transcripts, 2 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

 

 

 

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