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HomoloGene:5048. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

PMEL,  H.sapiens
premelanosome protein
NP_001186983.1
668 aa
PMEL,  P.troglodytes
premelanosome protein
XP_001169751.2
683 aa
PMEL,  M.mulatta
premelanosome protein
XP_001113158.1
703 aa
PMEL,  C.lupus
premelanosome protein
NP_001096686.1
658 aa
PMEL,  B.taurus
premelanosome protein
NP_001073684.2
649 aa
Pmel,  M.musculus
premelanosome protein
NP_068682.2
626 aa
Pmel,  R.norvegicus
premelanosome protein
NP_001102199.1
418 aa
PMEL,  G.gallus
premelanosome protein
NP_990443.2
763 aa
pmel,  X.tropicalis
premelanosome protein
XP_004911936.1
765 aa
pmelb,  D.rerio
premelanosome protein b
NP_001029090.2
616 aa
pmela,  D.rerio
premelanosome protein a
NP_001038795.1
825 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

[Detection of serum autoantibodies against premelanosome protein 17 increases in the vitiligo patients].
Hu L, et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 29, 411-3, 417 (2013).
Proprotein convertases process Pmel17 during secretion.
Leonhardt RM, et al. J Biol Chem 286, 9321-37 (2011).
Effects of pH on aggregation kinetics of the repeat domain of a functional amyloid, Pmel17.
Pfefferkorn CM, et al. Proc Natl Acad Sci U S A 107, 21447-52 (2010).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PKD (cl17457)
  polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.
HC2 (cl19298)
  Histone H1-like nucleoprotein HC2.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Pmel includes H.sapiens PMEL.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (12 transcripts, 11 species)
Actinopterygii - bony fishes (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

 

 

 

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