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HomoloGene:56469. Gene conserved in Tetrapoda Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

DES,  H.sapiens
desmin
NP_001918.3
470 aa
DES,  P.troglodytes
desmin
XP_526039.2
470 aa
DES,  M.mulatta
desmin
XP_001104181.1
470 aa
DES,  C.lupus
desmin
NP_001012394.1
469 aa
DES,  B.taurus
desmin
NP_001075044.1
470 aa
Des,  M.musculus
desmin
NP_034173.1
469 aa
Des,  R.norvegicus
desmin
NP_071976.1
469 aa
DES,  G.gallus
desmin
XP_004942895.1
479 aa
des.1,  X.tropicalis
desmin, gene 1
NP_989134.1
458 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Myopathy, desmin-related, cardioskeletal.
Cardiomyopathy, dilated, 1I.



Publications
Articles associated with genes and sequences of this homology group.

Role of the cytoskeleton in muscle transcriptional responses to altered use.
Meyer GA, et al. Physiol Genomics 45, 321-31 (2013).
Desmin mutations and arrhythmogenic right ventricular cardiomyopathy.
Lorenzon A, et al. Am J Cardiol 111, 400-5 (2013).
Skeletal muscle fibrosis develops in response to desmin deletion.
Meyer GA & Lieber RL. Am J Physiol Cell Physiol 302, C1609-20 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Filament (pfam00038)
  Intermediate filament protein.
Filament_head (pfam04732)
  Intermediate filament head (DNA binding) region.
Filament_head (pfam04732)
  Intermediate filament head (DNA binding) region.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Des includes H.sapiens DES and R.norvegicus Des.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (15 transcripts, 13 species)
Amphibia - amphibians (3 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Hyperoartia - vertebrates (1 transcript, 1 species)

 

 

 

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