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HomoloGene:11223. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

DGCR8,  H.sapiens
DGCR8 microprocessor complex subunit
NP_073557.3
773 aa
DGCR8,  P.troglodytes
DiGeorge syndrome critical region gene 8
XP_003953874.1
773 aa
DGCR8,  M.mulatta
DiGeorge syndrome critical region gene 8
XP_002798321.1
773 aa
DGCR8,  C.lupus
DiGeorge syndrome critical region gene 8
XP_543542.4
773 aa
DGCR8,  B.taurus
DiGeorge syndrome critical region gene 8
NP_001094674.1
760 aa
Dgcr8,  M.musculus
DiGeorge syndrome critical region gene 8
NP_201581.2
773 aa
Dgcr8,  R.norvegicus
DiGeorge syndrome critical region gene 8
NP_001099335.1
773 aa
DGCR8,  G.gallus
DiGeorge syndrome critical region gene 8
XP_415079.2
775 aa
dgcr8,  X.tropicalis
DGCR8 microprocessor complex subunit
NP_001153011.1
772 aa
dgcr8,  D.rerio
DiGeorge syndrome critical region gene 8
NP_001116221.1
782 aa
pasha,  D.melanogaster
partner of drosha
NP_001263150.1
642 aa
AgaP_AGAP002554,  A.gambiae
AgaP_AGAP002554
XP_312385.5
683 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.




Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
dsrm (pfam00035)
  Double-stranded RNA binding motif.
DSRM (cl00054)
  Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
WW (cl00157)
  Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Dgcr8 includes H.sapiens DGCR8 and R.norvegicus Dgcr8.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (12 transcripts, 10 species)
Actinopterygii - bony fishes (9 transcripts, 6 species)
Amphibia - amphibians (2 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)

Arthropoda
Insecta - insects (5 transcripts, 5 species)
Arachnida - arachnids (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

 

 

 

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