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HomoloGene:121568. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

EEF1A2,  H.sapiens
eukaryotic translation elongation factor 1 alpha 2
NP_001949.1
463 aa
EEF1A2,  P.troglodytes
eukaryotic translation elongation factor 1 alpha 2
XP_003954143.1
462 aa
LOC708096,  M.mulatta
elongation factor 1-alpha 1-like
XP_001107326.1
462 aa
LOC102156596,  C.lupus
elongation factor 1-alpha 1-like
XP_005617616.1
462 aa
EEF1A1,  C.lupus
eukaryotic translation elongation factor 1 alpha 1
NP_001184045.1
462 aa
LOC102155289,  C.lupus
elongation factor 1-alpha 1-like
XP_005618552.1
462 aa
EEF1A2,  B.taurus
eukaryotic translation elongation factor 1 alpha 2
NP_001032541.1
463 aa
Eef1a2,  M.musculus
eukaryotic translation elongation factor 1 alpha 2
NP_031932.1
463 aa
Eef1a2,  R.norvegicus
eukaryotic translation elongation factor 1 alpha 2
NP_036792.2
463 aa
EEF1A2,  G.gallus
eukaryotic translation elongation factor 1 alpha 2
NP_001027570.1
463 aa
eef1a2,  X.tropicalis
eukaryotic translation elongation factor 1 alpha 2
NP_001011418.1
463 aa
eef1a2,  D.rerio
eukaryotic translation elongation factor 1 alpha 2
NP_001002371.1
463 aa
Ef1alpha100E,  D.melanogaster
Elongation factor 1alpha100E
NP_524611.1
462 aa
AgaP_AGAP003541,  A.gambiae
AgaP_AGAP003541
XP_003436515.1
462 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

D.melanogaster
Encodes an α unit of the heterotrimeric protein, elongation factor 1; isolated by homology with Ef1α1. Expressed primarily in pupae; low levels of mRNA detectable in third instar larvae and adults. There is 90% aa similarity with EF1α.



Publications
Articles associated with genes and sequences of this homology group.

eEF1A2 as a putative oncogene.
Lee MH & Surh YJ. Ann N Y Acad Sci 1171, 87-93 (2009).
Regulation and functional role of eEF1A2 in pancreatic carcinoma.
Cao H, et al. Biochem Biophys Res Commun 380, 11-6 (2009).
Effects of cardiovascular medications on rate of functional decline in Alzheimer disease.
Rosenberg PB, et al. Am J Geriatr Psychiatry 16, 883-92 (2008).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Translation_factor_III (cl02786)
  Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G. Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu ...
Translation_Factor_II_like (cl02787)
  Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to ...
Ras_like_GTPase (cl17170)
  Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases).



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Eef1a2 includes H.sapiens EEF1A2 and R.norvegicus Eef1a2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (22 transcripts, 12 species)
Actinopterygii - bony fishes (12 transcripts, 7 species)
Amphibia - amphibians (8 transcripts, 2 species)
Ascidiacea - tunicates (3 transcripts, 3 species)
Aves - birds (3 transcripts, 3 species)
Cephalochordata - lancelets (2 transcripts, 1 species)
Hyperoartia - vertebrates (2 transcripts, 1 species)
Amniota - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (16 transcripts, 10 species)
Arachnida - arachnids (3 transcripts, 2 species)
Branchiopoda - crustaceans (3 transcripts, 1 species)
Maxillopoda - crustaceans (2 transcripts, 1 species)
Malacostraca - crustaceans (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (5 transcripts, 1 species)
Hydrozoa - hydrozoans (3 transcripts, 1 species)

Platyhelminthes
Trematoda - flatworms (5 transcripts, 2 species)

Annelida
Polychaeta - segmented worms (2 transcripts, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (14 transcripts, 7 species)
Liliopsida - monocots (12 transcripts, 7 species)
Coniferopsida - conifers (10 transcripts, 3 species)
Bryopsida - mosses (1 transcript, 1 species)

Chlorophyta
Chlorophyceae - green algae (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (2 transcripts, 1 species)

Oomycetes
Peronosporales - oomycetes (2 transcripts, 1 species)

Codonosigidae
Monosiga - choanoflagellates (1 transcript, 1 species)

 

 

 

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