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HomoloGene:966. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

CDKN2C,  H.sapiens
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
NP_001253.1
168 aa
CDKN2C,  P.troglodytes
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
XP_524704.2
168 aa
CDKN2C,  M.mulatta
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
XP_001110979.1
168 aa
CDKN2C,  C.lupus
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
XP_849772.1
168 aa
CDKN2C,  B.taurus
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
NP_001094524.1
168 aa
Cdkn2c,  M.musculus
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
NP_031697.1
168 aa
Cdkn2c,  R.norvegicus
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
NP_571977.1
168 aa
CDKN2C,  G.gallus
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
XP_004936837.1
167 aa
cdkn2c,  X.tropicalis
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
NP_001116932.1
168 aa
cdkn2c,  D.rerio
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
NP_001186923.1
170 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Expression of p18(INK4C) is down-regulated in human pituitary adenomas.
Hossain MG, et al. Endocr Pathol 20, 114-21 (2009).
Frequent loss of the CDKN2C (p18INK4c) gene product in pituitary adenomas.
Kirsch M, et al. Genes Chromosomes Cancer 48, 143-54 (2009).
Deletions of CDKN2C in multiple myeloma: biological and clinical implications.
Leone PE, et al. Clin Cancer Res 14, 6033-41 (2008).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Ank_2 (pfam12796)
  Ankyrin repeats (3 copies).
Ank_5 (pfam13857)
  Ankyrin repeats (many copies).
Ank_4 (pfam13637)
  Ankyrin repeats (many copies).
ANK (cd00204)
  ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
Ank_2 (pfam12796)
  Ankyrin repeats (3 copies).
Ank_4 (pfam13637)
  Ankyrin repeats (many copies).



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Cdkn2c includes H.sapiens CDKN2C and R.norvegicus Cdkn2c.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (11 transcripts, 10 species)
Amphibia - amphibians (2 transcripts, 1 species)
Actinopterygii - bony fishes (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

 

 

 

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