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HomoloGene:55699. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

RAC2,  H.sapiens
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
NP_002863.1
192 aa
RAC2,  M.mulatta
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
XP_001086228.1
192 aa
RAC2,  C.lupus
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
XP_538392.4
192 aa
RAC2,  B.taurus
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
NP_786986.1
192 aa
Rac2,  M.musculus
RAS-related C3 botulinum substrate 2
NP_033034.1
192 aa
Rac2,  R.norvegicus
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
NP_001008385.1
192 aa
RAC2,  G.gallus
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
NP_001188381.1
192 aa
rac2,  X.tropicalis
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
NP_001011285.1
192 aa
rac2,  D.rerio
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
NP_001002061.1
192 aa
MGG_02731,  M.oryzae
MGG_02731
XP_003721025.1
199 aa
NCU02160,  N.crassa
NCU02160
XP_964519.2
197 aa
RAC10,  A.thaliana
RAC10
NP_201093.1
215 aa
ROP10,  A.thaliana
ROP10
NP_566897.1
208 aa
Os02g0742200,  O.sativa
Os02g0742200
NP_001048088.1
214 aa
Os06g0234200,  O.sativa
Os06g0234200
NP_001057236.1
215 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Neutrophil immunodeficiency syndrome.



Publications
Articles associated with genes and sequences of this homology group.

Rac GTPases in human diseases.
Pai SY, et al. Dis Markers 29, 177-87 (2010).
Osteoclasts lacking Rac2 have defective chemotaxis and resorptive activity.
Itokowa T, et al. Calcif Tissue Int 88, 75-86 (2011).
Regulation of inflammation by Rac2 in immune complex-mediated acute lung injury.
Dooley JL, et al. Am J Physiol Lung Cell Mol Physiol 297, L1091-102 (2009).
Primary granule exocytosis in human neutrophils is regulated by Rac-dependent actin remodeling.
Mitchell T, et al. Am J Physiol Cell Physiol 295, C1354-65 (2008).
Rho GTPase-mediated pathways in mature CD4+ T cells.
Pernis AB. Autoimmun Rev 8, 199-203 (2009).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
P-loop_NTPase (cl09099)
  P-loop containing Nucleoside Triphosphate Hydrolases.
Ras_like_GTPase (cl17170)
  Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases).



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Rac2 includes H.sapiens RAC2 and R.norvegicus Rac2.

 

 

 

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