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HomoloGene:20137. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

AQP2,  H.sapiens
aquaporin 2 (collecting duct)
NP_000477.1
271 aa
AQP2,  P.troglodytes
aquaporin 2 (collecting duct)
XP_001157340.2
263 aa
AQP2,  M.mulatta
aquaporin 2 (collecting duct)
XP_001110572.1
271 aa
AQP2,  C.lupus
aquaporin 2 (collecting duct)
XP_543678.2
271 aa
AQP2,  B.taurus
aquaporin 2 (collecting duct)
NP_001094669.1
271 aa
Aqp2,  M.musculus
aquaporin 2
NP_033829.3
271 aa
Aqp2,  R.norvegicus
aquaporin 2 (collecting duct)
NP_037041.2
271 aa
AQP2,  G.gallus
aquaporin 2 (collecting duct)
XP_428855.4
276 aa
aqp2,  X.tropicalis
aquaporin 2 (collecting duct)
NP_001015749.1
273 aa
DELTA-TIP,  A.thaliana
DELTA-TIP
NP_188245.1
250 aa
TIP2;2,  A.thaliana
TIP2;2
NP_193465.1
250 aa
TIP2;3,  A.thaliana
TIP2;3
NP_199556.1
250 aa
Os04g0550950,  O.sativa
Os04g0550950
NP_001174036.1
249 aa
Os02g0658100,  O.sativa
Os02g0658100
NP_001047632.1
248 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Diabetes insipidus, nephrogenic.
Diabetes insipidus, nephrogenic, autosomal recessive.



Publications
Articles associated with genes and sequences of this homology group.

Excretion of urinary exosomal AQP2 in rats is regulated by vasopressin and urinary pH.
Higashijima Y, et al. Am J Physiol Renal Physiol 305, F1412-21 (2013).
New insights into regulated aquaporin-2 function.
Fenton RA, et al. Curr Opin Nephrol Hypertens 22, 551-8 (2013).
Altered urinary excretion of aquaporin 2 in IgA nephropathy.
Rocchetti MT, et al. Eur J Endocrinol 165, 657-64 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
MIP (cl00200)
  Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Aqp2 includes H.sapiens AQP2 and R.norvegicus Aqp2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Streptophyta
Eudicotyledons - eudicots (56 transcripts, 29 species)
Liliopsida - monocots (12 transcripts, 6 species)
Bryopsida - mosses (5 transcripts, 1 species)
Coniferopsida - conifers (2 transcripts, 2 species)

Chordata
Mammalia - mammals (11 transcripts, 10 species)
Aves - birds (2 transcripts, 1 species)
Amphibia - amphibians (2 transcripts, 2 species)

Annelida
Polychaeta - segmented worms (2 transcripts, 1 species)

Arthropoda
Insecta - insects (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

 

 

 

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