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HomoloGene:317. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

TTR,  H.sapiens
transthyretin
NP_000362.1
147 aa
TTR,  P.troglodytes
transthyretin
NP_001009137.1
147 aa
TTR,  M.mulatta
transthyretin
XP_001099005.1
147 aa
TTR,  C.lupus
transthyretin
XP_537290.1
147 aa
TTR,  B.taurus
transthyretin
NP_776392.1
147 aa
Ttr,  M.musculus
transthyretin
NP_038725.1
147 aa
Ttr,  R.norvegicus
transthyretin
NP_036813.2
147 aa
TTR,  G.gallus
transthyretin
NP_990666.1
150 aa
ttr,  X.tropicalis
transthyretin
NP_001096539.1
151 aa
ttr,  D.rerio
transthyretin (prealbumin, amyloidosis type I)
NP_001005598.2
149 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Amyloid neuropathy, familial, several allelic types.
Amyloidosis, senile systemic.
Carpal tunnel syndrome, familial.
Dystransthyretinemic hyperthyroxinemia.



Publications
Articles associated with genes and sequences of this homology group.

Genetic stabilization of transthyretin, cerebrovascular disease, and life expectancy.
Hornstrup LS, et al. Arterioscler Thromb Vasc Biol 33, 1441-7 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Transthyretin_like (cl17222)
  Transthyretin_like. This domain is present in the transthyretin-like protein (TLP) family which includes transthyretin (TTR) and a transthyretin-related protein called 5-hydroxyisourate hydrolase (HIUase). TTR and HIUase are homotetrameric proteins ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Ttr includes H.sapiens TTR and R.norvegicus Ttr.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (20 transcripts, 17 species)
Actinopterygii - bony fishes (3 transcripts, 3 species)
Aves - birds (3 transcripts, 3 species)
Amniota - vertebrates (2 transcripts, 1 species)
Amphibia - amphibians (2 transcripts, 2 species)

 

 

 

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