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HomoloGene:18400. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

SLC24A5,  H.sapiens
solute carrier family 24 (sodium/potassium/calcium exchanger), member 5
NP_995322.1
500 aa
SLC24A5,  P.troglodytes
solute carrier family 24, member 5
XP_510380.2
500 aa
SLC24A5,  M.mulatta
solute carrier family 24, member 5
XP_001112601.1
500 aa
SLC24A5,  C.lupus
solute carrier family 24 (sodium/potassium/calcium exchanger), member 5
XP_851849.1
501 aa
SLC24A5,  B.taurus
solute carrier family 24, member 5
NP_001121981.1
501 aa
Slc24a5,  M.musculus
solute carrier family 24, member 5
NP_778199.2
501 aa
SLC24A5,  G.gallus
solute carrier family 24, member 5
NP_001033586.2
500 aa
slc24a5,  X.tropicalis
solute carrier family 24, member 5
XP_002936612.2
546 aa
slc24a5,  D.rerio
solute carrier family 24, member 5
NP_001025451.1
513 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Pigmentation of skin, variation in.



Publications
Articles associated with genes and sequences of this homology group.

SLC24A5 mutations are associated with non-syndromic oculocutaneous albinism.
Morice-Picard F, et al. J Invest Dermatol 134, 568-71 (2014).
Repression of Slc24a5 can reduce pigmentation in chicken.
Liu XF, et al. Front Biosci (Elite Ed) 3, 158-65 (2011).
Ocular albinism and hypopigmentation defects in Slc24a5-/- mice.
Vogel P, et al. Vet Pathol 45, 264-79 (2008).
A golden clue to human skin colour variation.
Müller J & Kelsh RN. Bioessays 28, 578-82 (2006).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Na_Ca_ex (pfam01699)
  Sodium/calcium exchanger protein.
Na_Ca_ex (pfam01699)
  Sodium/calcium exchanger protein.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Slc24a5 includes H.sapiens SLC24A5.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (12 transcripts, 10 species)
Actinopterygii - bony fishes (6 transcripts, 5 species)
Aves - birds (2 transcripts, 1 species)
Amphibia - amphibians (2 transcripts, 1 species)
Amniota - vertebrates (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (4 transcripts, 4 species)
Arachnida - arachnids (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (2 transcripts, 2 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

 

 

 

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