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HomoloGene:2016. Gene conserved in Opisthokonta Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

POLG,  H.sapiens
polymerase (DNA directed), gamma
NP_001119603.1
1239 aa
POLG,  P.troglodytes
polymerase (DNA directed), gamma
XP_523149.2
1236 aa
POLG,  M.mulatta
polymerase (DNA directed), gamma
XP_001092360.1
1228 aa
POLG,  C.lupus
polymerase (DNA directed), gamma
XP_005618410.1
1241 aa
POLG,  B.taurus
polymerase (DNA directed), gamma
XP_002696610.2
1248 aa
Polg,  M.musculus
polymerase (DNA directed), gamma
NP_059490.2
1217 aa
Polg,  R.norvegicus
polymerase (DNA directed), gamma
NP_445980.1
1216 aa
POLG,  G.gallus
polymerase (DNA directed), gamma
XP_425079.4
929 aa
LOC100488393,  X.tropicalis
DNA polymerase subunit gamma-1-like
XP_002932281.2
1197 aa
polg,  D.rerio
polymerase (DNA directed), gamma
XP_001921130.3
1206 aa
tam,  D.melanogaster
tamas
NP_476821.1
1145 aa
AgaP_AGAP000139,  A.gambiae
AgaP_AGAP000139
XP_311006.5
1161 aa
MIP1,  S.cerevisiae
MIP1
NP_014975.2
1254 aa
AGOS_ADR357C,  E.gossypii
AGOS_ADR357C
NP_984453.1
1131 aa
pog1,  S.pombe
pog1
NP_588025.2
1018 aa
MGG_08913,  M.oryzae
MGG_08913
XP_003713942.1
1147 aa
NCU00276,  N.crassa
NCU00276
XP_957747.2
1456 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Progressive external ophthalmoplegia with mitochondrial DNA deletions.
Alpers syndrome.
Sensory ataxic neuropathy, dysarthria, and ophthalmoparesis.
Spinocerebellar ataxia with epilepsy.



Publications
Articles associated with genes and sequences of this homology group.

Mitochondrial regulation in pluripotent stem cells.
Xu X, et al. Cell Metab 18, 325-32 (2013).
The clinical and audiologic features of hearing loss due to mitochondrial mutations.
Yelverton JC, et al. Otolaryngol Head Neck Surg 148, 1017-22 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
DNA_pol_A (cl02626)
  Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication.
DnaQ_like_exo (cl10012)
  DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily.
DNA_pol_A (cl02626)
  Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication.
DnaQ_like_exo (cl10012)
  DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Polg includes H.sapiens POLG and R.norvegicus Polg.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (12 transcripts, 11 species)
Actinopterygii - bony fishes (9 transcripts, 6 species)
Ascidiacea - tunicates (3 transcripts, 1 species)
Aves - birds (2 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (8 transcripts, 7 species)
Arachnida - arachnids (2 transcripts, 2 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (2 transcripts, 2 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 2 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)
Hirudinida - segmented worms (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (1 transcript, 1 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Codonosigidae
Monosiga - choanoflagellates (1 transcript, 1 species)

 

 

 

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