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HomoloGene:8382. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

KCNIP3,  H.sapiens
Kv channel interacting protein 3, calsenilin
256 aa
KCNIP3,  P.troglodytes
Kv channel interacting protein 3, calsenilin
256 aa
KCNIP3,  M.mulatta
Kv channel interacting protein 3, calsenilin
256 aa
KCNIP3,  C.lupus
Kv channel interacting protein 3, calsenilin
284 aa
KCNIP3,  B.taurus
Kv channel interacting protein 3, calsenilin
255 aa
Kcnip3,  M.musculus
Kv channel interacting protein 3, calsenilin
256 aa
Kcnip3,  R.norvegicus
Kv channel interacting protein 3, calsenilin
256 aa
LOC100494097,  X.tropicalis
285 aa
kcnip3a,  D.rerio
Kv channel interacting protein 3a, calsenilin
257 aa
kcnip3b,  D.rerio
Kv channel interacting protein 3b, calsenilin
259 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

Calsenilin contributes to neuronal cell death in ischemic stroke.
Park JS, et al. Brain Pathol 23, 402-12 (2013).
Hyperglycemia induces early upregulation of the calcium sensor KChIP3/DREAM/calsenilin in the rat retina.
Chavira-Suárez E, et al. Biochem Biophys Res Commun 418, 420-5 (2012).
The role of calsenilin/DREAM/KChIP3 in contextual fear conditioning.
Alexander JC, et al. Learn Mem 16, 167-77 (2009).
Lack of DREAM protein enhances learning and memory and slows brain aging.
Fontán-Lozano A, et al. Curr Biol 19, 54-60 (2009).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
FRQ1 (COG5126)
  Ca2+-binding protein (EF-Hand superfamily) [Signal transduction mechanisms / Cytoskeleton / Cell division and chromosome partitioning / General function prediction only].
EFh (cd00051)
  EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
EF-hand_8 (cl17302)
  EF-hand domain pair.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Kcnip3 includes H.sapiens KCNIP3 and R.norvegicus Kcnip3.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (9 transcripts, 8 species)
Actinopterygii - bony fishes (7 transcripts, 4 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Insecta - insects (1 transcript, 1 species)




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