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HomoloGene:171. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

CFI,  H.sapiens
complement factor I
NP_000195.2
583 aa
CFI,  P.troglodytes
complement factor I
XP_003310493.1
591 aa
CFI,  C.lupus
complement factor I
XP_005639326.1
591 aa
CFI,  B.taurus
complement factor I
NP_001033185.1
618 aa
Cfi,  M.musculus
complement component factor i
NP_031712.2
603 aa
Cfi,  R.norvegicus
complement factor I
NP_077071.1
604 aa
CFI,  G.gallus
complement factor I
NP_001258947.1
596 aa
cfi,  X.tropicalis
complement factor I
NP_001027508.1
602 aa
cfi,  D.rerio
complement factor I
XP_002667431.3
673 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
C3b inactivator deficiency.



Publications
Articles associated with genes and sequences of this homology group.

Genetic factors for choroidal neovascularization associated with high myopia.
Leveziel N, et al. Invest Ophthalmol Vis Sci 53, 5004-9 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
FIMAC (smart00057)
  factor I membrane attack complex.
Tryp_SPc (smart00020)
  Trypsin-like serine protease.
Tryp_SPc (cd00190)
  Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
LDLa (cl00104)
  Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure
SRCR (cl02509)
  Scavenger receptor cysteine-rich domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Cfi includes H.sapiens CFI and R.norvegicus Cfi.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (13 transcripts, 11 species)
Amniota - vertebrates (1 transcript, 1 species)

 

 

 

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