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HomoloGene:37593. Gene conserved in Tetrapoda Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

ITPR2,  H.sapiens
inositol 1,4,5-trisphosphate receptor, type 2
2701 aa
ITPR2,  P.troglodytes
inositol 1,4,5-trisphosphate receptor, type 2
2634 aa
ITPR2,  M.mulatta
inositol 1,4,5-trisphosphate receptor, type 2
2700 aa
ITPR2,  C.lupus
inositol 1,4,5-trisphosphate receptor, type 2
2701 aa
ITPR2,  B.taurus
inositol 1,4,5-trisphosphate receptor, type 2
2701 aa
Itpr2,  M.musculus
inositol 1,4,5-triphosphate receptor 2
2701 aa
Itpr2,  R.norvegicus
inositol 1,4,5-trisphosphate receptor, type 2
2701 aa
ITPR2,  G.gallus
inositol 1,4,5-trisphosphate receptor, type 2
2712 aa
itpr2,  X.tropicalis
inositol 1,4,5-trisphosphate receptor, type 2
1945 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

Neuronal overexpression of IP₃ receptor 2 is detrimental in mutant SOD1 mice.
Staats KA, et al. Biochem Biophys Res Commun 429, 210-3 (2012).
General anesthesia selectively disrupts astrocyte calcium signaling in the awake mouse cortex.
Thrane AS, et al. Proc Natl Acad Sci U S A 109, 18974-9 (2012).
Astrocytes mediate in vivo cholinergic-induced synaptic plasticity.
Navarrete M, et al. PLoS Biol 10, e1001259 (2012).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
DUF3792 (pfam12670)
  Protein of unknown function (DUF3792).
RYDR_ITPR (pfam01365)
  RIH domain.
RIH_assoc (pfam08454)
  RyR and IP3R Homology associated.
Ion_trans (pfam00520)
  Ion transport protein.
RYDR_ITPR (pfam01365)
  RIH domain.
RIH_assoc (pfam08454)
  RyR and IP3R Homology associated.
Abi (cl00558)
  Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases). The family contains the CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin. Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity.
Ins145_P3_rec (cl19745)
  Inositol 1,4,5-trisphosphate/ryanodine receptor.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Itpr2 includes H.sapiens ITPR2 and R.norvegicus Itpr2.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Actinopterygii - bony fishes (24 transcripts, 8 species)
Mammalia - mammals (12 transcripts, 9 species)
Aves - birds (3 transcripts, 1 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Ascidiacea - tunicates (1 transcript, 1 species)

Insecta - insects (1 transcript, 1 species)
Arachnida - arachnids (1 transcript, 1 species)
Malacostraca - crustaceans (1 transcript, 1 species)

Demospongiae - sponges (2 transcripts, 1 species)

Polychaeta - segmented worms (1 transcript, 1 species)
Hirudinida - segmented worms (1 transcript, 1 species)

Anthozoa - anthozoans (1 transcript, 1 species)




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