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HomoloGene:207. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

CIITA,  H.sapiens
class II, major histocompatibility complex, transactivator
NP_001273331.1
1131 aa
CIITA,  P.troglodytes
class II, major histocompatibility complex, transactivator
XP_510813.2
1130 aa
CIITA,  M.mulatta
class II, major histocompatibility complex, transactivator
XP_001103518.2
1159 aa
CIITA,  C.lupus
class II, major histocompatibility complex, transactivator
XP_005621604.1
1206 aa
CIITA,  B.taurus
class II, major histocompatibility complex, transactivator
XP_002698008.2
1232 aa
Ciita,  M.musculus
class II transactivator
NP_001230689.1
1154 aa
Ciita,  R.norvegicus
class II, major histocompatibility complex, transactivator
NP_445981.2
1153 aa
LOC416633,  G.gallus
class II, major histocompatibility complex, transactivator-like
XP_004945372.1
1171 aa
ciita,  X.tropicalis
class II, major histocompatibility complex, transactivator
XP_004918329.1
574 aa
ciita,  D.rerio
class II, major histocompatibility complex, transactivator
XP_005163972.1
1138 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Multiple sclerosis, susceptibility to.
Rheumatoid arthritis, susceptibility to.
Bare lymphocyte syndrome, type II, complementation group A.



Publications
Articles associated with genes and sequences of this homology group.

Transcriptional coactivator CIITA, a functional homolog of TAF1, has kinase activity.
Soe KC, et al. Biochim Biophys Acta 1829, 1184-90 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
LRR_4 (pfam12799)
  Leucine Rich repeats (2 copies).
LRR_8 (pfam13855)
  Leucine rich repeat.
NACHT (pfam05729)
  NACHT domain.
LRR_RI (cd00116)
  Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
LRR_RI (cl15309)
  Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
ABC_ATPase (cl17201)
  ATP-binding cassette transporter nucleotide-binding domain.
LRR_8 (pfam13855)
  Leucine rich repeat.
AAA (cl18944)
  The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Ciita includes H.sapiens CIITA and R.norvegicus Ciita.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (7 transcripts, 7 species)
Actinopterygii - bony fishes (2 transcripts, 2 species)

 

 

 

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