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HomoloGene:7909. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

PTPN13,  H.sapiens
protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
NP_542416.1
2490 aa
PTPN13,  P.troglodytes
protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
XP_003950411.1
2485 aa
PTPN13,  M.mulatta
tyrosine-protein phosphatase non-receptor type 13-like
XP_002808460.1
2492 aa
PTPN13,  C.lupus
protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
XP_005639208.1
2512 aa
PTPN13,  B.taurus
protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
NP_777015.2
2512 aa
Ptpn13,  M.musculus
protein tyrosine phosphatase, non-receptor type 13
NP_035334.2
2451 aa
Ptpn13,  R.norvegicus
protein tyrosine phosphatase, non-receptor type 13
NP_001094259.1
2455 aa
PTPN13,  G.gallus
protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
XP_003641237.2
2549 aa
ptpn13,  X.tropicalis
protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
XP_002936504.2
2284 aa
ptpn13,  D.rerio
protein tyrosine phosphatase, non-receptor type 13
NP_001083012.2
2317 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

PTPN13/PTPL1: an important regulator of tumor aggressiveness.
Freiss G & Chalbos D. Anticancer Agents Med Chem 11, 78-88 (2011).
Downregulation of protein tyrosine phosphatase PTP-BL represses adipogenesis.
Glondu-Lassis M, et al. Int J Biochem Cell Biol 41, 2173-80 (2009).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PTPc (smart00194)
  Protein tyrosine phosphatase, catalytic domain.
FERM_M (pfam00373)
  FERM central domain.
FERM_N (pfam09379)
  FERM N-terminal domain.
vWFA (cl00057)
  Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
FERM_M (pfam00373)
  FERM central domain.
FERM_N (pfam09379)
  FERM N-terminal domain.
PDZ (cl00117)
  PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
PKc_like (cl09925)
  Protein Kinases, catalytic domain.
PH-like (cl17171)
  Pleckstrin homology-like domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Ptpn13 includes H.sapiens PTPN13 and R.norvegicus Ptpn13.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (15 transcripts, 12 species)
Actinopterygii - bony fishes (5 transcripts, 3 species)
Amniota - vertebrates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

 

 

 

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