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HomoloGene:68300. Gene conserved in Boreoeutheria Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

SPINK1,  H.sapiens
serine peptidase inhibitor, Kazal type 1
79 aa
SPINK1,  P.troglodytes
serine peptidase inhibitor, Kazal type 1
79 aa
SPINK1,  M.mulatta
serine peptidase inhibitor, Kazal type 1
79 aa
SPINK1,  C.lupus
serine peptidase inhibitor, Kazal type 1
80 aa
SPINK1,  B.taurus
serine peptidase inhibitor, Kazal type 1
79 aa
Spink3,  M.musculus
serine peptidase inhibitor, Kazal type 3
80 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

Fibrocalculous pancreatic diabetes, susceptibility to.
Pancreatitis, hereditary.
Tropical calcific pancreatitis.

Articles associated with genes and sequences of this homology group.

The N34S mutation of the SPINK1 gene and alcoholic chronic pancreatitis.
Cicho┼╝-Lach H, et al. Pol Arch Med Wewn 122, 277-83 (2012).
Do genetic variants in the SPINK1 gene affect the level of serum PSTI?
Kume K, et al. J Gastroenterol 47, 1267-74 (2012).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
KAZAL_FS (cl00097)
  Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Spink3 includes H.sapiens SPINK1 and R.norvegicus Spink3.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (12 transcripts, 8 species)




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