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HomoloGene:3987. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

SNCAIP,  H.sapiens
synuclein, alpha interacting protein
NP_005451.2
919 aa
SNCAIP,  M.mulatta
synuclein, alpha interacting protein
XP_001090698.1
1017 aa
SNCAIP,  C.lupus
synuclein, alpha interacting protein
XP_538600.3
966 aa
SNCAIP,  B.taurus
synuclein, alpha interacting protein
NP_001192707.1
919 aa
Sncaip,  M.musculus
synuclein, alpha interacting protein (synphilin)
NP_001186082.1
965 aa
Sncaip,  R.norvegicus
synuclein, alpha interacting protein
NP_001100849.1
963 aa
SNCAIP,  G.gallus
synuclein, alpha interacting protein
XP_424409.3
960 aa
sncaip,  X.tropicalis
synuclein, alpha interacting protein
NP_001005712.1
898 aa
zgc:172291,  D.rerio
zgc:172291
NP_001107108.1
738 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Parkinson disease.



Publications
Articles associated with genes and sequences of this homology group.

A novel obesity model: synphilin-1-induced hyperphagia and obesity in mice.
Li X, et al. Int J Obes (Lond) 36, 1215-21 (2012).
The role of synphilin-1 in synaptic function and protein degradation.
Kr├╝ger R. Cell Tissue Res 318, 195-9 (2004).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Ank_2 (pfam12796)
  Ankyrin repeats (3 copies).
Ank_4 (pfam13637)
  Ankyrin repeats (many copies).
ANK (cd00204)
  ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
Ank_2 (pfam12796)
  Ankyrin repeats (3 copies).
Ank_4 (pfam13637)
  Ankyrin repeats (many copies).



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Sncaip includes H.sapiens SNCAIP and R.norvegicus Sncaip.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (11 transcripts, 10 species)
Actinopterygii - bony fishes (3 transcripts, 3 species)
Aves - birds (3 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

 

 

 

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