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HomoloGene:20100. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

MYO5A,  H.sapiens
myosin VA (heavy chain 12, myoxin)
NP_000250.3
1855 aa
MYO5A,  P.troglodytes
myosin VA (heavy chain 12, myoxin)
XP_510412.2
1855 aa
MYO5A,  M.mulatta
myosin VA (heavy chain 12, myoxin)
XP_001084476.1
1835 aa
MYO5A,  C.lupus
myosin VA (heavy chain 12, myoxin)
XP_005638745.1
2213 aa
MYO5A,  B.taurus
myosin VA (heavy chain 12, myoxin)
XP_005211933.1
1880 aa
Myo5a,  M.musculus
myosin VA
NP_034994.2
1853 aa
Myo5a,  R.norvegicus
myosin VA
NP_071514.1
1828 aa
MYO5A,  G.gallus
myosin VA (heavy chain 12, myosin)
NP_990631.1
1829 aa
myo5a,  X.tropicalis
myosin VA (heavy chain 12, myoxin)
XP_004912752.1
1853 aa
myo5aa,  D.rerio
myosin VAa
XP_005173731.1
1891 aa
didum,  D.melanogaster
dilute class unconventional myosin
NP_724569.1
1800 aa
AgaP_AGAP006479,  A.gambiae
AgaP_AGAP006479
XP_316519.4
1792 aa
hum-2,  C.elegans
hum-2
NP_001023886.1
1839 aa
MYO2,  S.cerevisiae
MYO2
NP_014971.1
1574 aa
KLLA0A03905g,  K.lactis
KLLA0A03905g
XP_451171.1
1550 aa
AGOS_ADR354W,  E.gossypii
AGOS_ADR354W
NP_984450.1
1558 aa
MGG_16213,  M.oryzae
MGG_16213
XP_003709659.1
1590 aa
NCU11354,  N.crassa
NCU11354
XP_001728528.1
1442 aa
XIE,  A.thaliana
XIE
NP_175858.1
1529 aa
XIC,  A.thaliana
XIC
NP_172349.2
1538 aa
Os06g0488200,  O.sativa
Os06g0488200
NP_001057670.1
1529 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Griscelli syndrome, type 1.



Publications
Articles associated with genes and sequences of this homology group.

Structural basis of cargo recognitions for class V myosins.
Wei Z, et al. Proc Natl Acad Sci U S A 110, 11314-9 (2013).
Roles for myosin Va in RNA transport and turnover.
McCaffrey MW & Lindsay AJ. Biochem Soc Trans 40, 1416-20 (2012).
Full-length myosin Va exhibits altered gating during processive movement on actin.
Armstrong JM, et al. Proc Natl Acad Sci U S A 109, E218-24 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Myosin_N (pfam02736)
  Myosin N-terminal SH3-like domain.
TPR_MLP1_2 (pfam07926)
  TPR/MLP1/MLP2-like protein.
TMF_TATA_bd (pfam12325)
  TATA element modulatory factor 1 TATA binding.
IQ (cl15479)
  IQ calmodulin-binding motif.
DIL (pfam01843)
  DIL domain.
THOC7 (pfam05615)
  Tho complex subunit 7.
DUF972 (pfam06156)
  Protein of unknown function (DUF972).
DIL (pfam01843)
  DIL domain.
Myosin_N (pfam02736)
  Myosin N-terminal SH3-like domain.
TPR_MLP1_2 (pfam07926)
  TPR/MLP1/MLP2-like protein.
Jnk-SapK_ap_N (pfam09744)
  JNK_SAPK-associated protein-1.
LRS4 (pfam10422)
  Monopolin complex subunit LRS4.
Motor_domain (cl00286)
  Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes.
GrpE (cl03075)
  GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding. ...
IQ (cl15479)
  Calmodulin-binding motif.
Ras_like_GTPase (cl17170)
  Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases).
ApoLp-III_like (cl19113)
  Apolipophorin-III and similar insect proteins.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Myo5a includes H.sapiens MYO5A and R.norvegicus Myo5a.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (18 transcripts, 9 species)
Mammalia - mammals (17 transcripts, 13 species)
Amphibia - amphibians (3 transcripts, 2 species)
Ascidiacea - tunicates (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

Arthropoda
Insecta - insects (7 transcripts, 7 species)
Arachnida - arachnids (1 transcript, 1 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (2 transcripts, 1 species)
Hirudinida - segmented worms (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (2 transcripts, 1 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Oomycetes
Peronosporales - oomycetes (2 transcripts, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (2 transcripts, 1 species)

 

 

 

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