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HomoloGene:2435. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

TGFBR2,  H.sapiens
transforming growth factor, beta receptor II (70/80kDa)
NP_001020018.1
592 aa
TGFBR2,  P.troglodytes
transforming growth factor, beta receptor II (70/80kDa)
XP_516343.2
592 aa
TGFBR2,  M.mulatta
transforming growth factor, beta receptor II (70/80kDa)
XP_001095877.1
592 aa
TGFBR2,  C.lupus
transforming growth factor, beta receptor II (70/80kDa)
XP_005634388.1
561 aa
TGFBR2,  B.taurus
transforming growth factor, beta receptor II (70/80kDa)
NP_001153038.1
567 aa
Tgfbr2,  M.musculus
transforming growth factor, beta receptor II
NP_033397.3
592 aa
Tgfbr2,  R.norvegicus
transforming growth factor, beta receptor II
NP_112394.3
567 aa
TGFBR2,  G.gallus
transforming growth factor, beta receptor II (70/80kDa)
NP_990759.1
557 aa
tgfbr2,  X.tropicalis
transforming growth factor, beta receptor II (70/80kDa)
XP_002941621.2
718 aa
tgfbr2,  D.rerio
transforming growth factor, beta receptor II
NP_878275.2
556 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Esophageal cancer.
Marfan syndrome, type II.
Colon cancer.
Colorectal cancer, hereditary nonpolyposis, type 6.
Aortic aneurysm, familial thoracic 3.
Loeys-Dietz syndrome.



Publications
Articles associated with genes and sequences of this homology group.

Biliary epithelial senescence and plasticity in acute cellular rejection.
Brain JG, et al. Am J Transplant 13, 1688-702 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
ecTbetaR2 (pfam08917)
  Transforming growth factor beta receptor 2 ectodomain.
Pkinase (pfam00069)
  Protein kinase domain.
Pkinase (pfam00069)
  Protein kinase domain.
PKc_like (cl09925)
  Protein Kinases, catalytic domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Tgfbr2 includes H.sapiens TGFBR2 and R.norvegicus Tgfbr2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (13 transcripts, 11 species)
Actinopterygii - bony fishes (13 transcripts, 9 species)
Ascidiacea - tunicates (2 transcripts, 2 species)
Aves - birds (2 transcripts, 1 species)
Amniota - vertebrates (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

 

 

 

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