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HomoloGene:283. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

SCN4A,  H.sapiens
sodium channel, voltage-gated, type IV, alpha subunit
NP_000325.4
1836 aa
SCN4A,  P.troglodytes
sodium channel, voltage-gated, type IV, alpha subunit
XP_003315741.1
1697 aa
SCN4A,  M.mulatta
sodium channel, voltage-gated, type IV, alpha subunit
XP_001116451.1
1837 aa
SCN4A,  C.lupus
sodium channel, voltage-gated, type IV, alpha subunit
XP_853396.1
1837 aa
SCN4A,  B.taurus
sodium channel, voltage-gated, type IV, alpha subunit
XP_003587508.1
1834 aa
Scn4a,  M.musculus
sodium channel, voltage-gated, type IV, alpha
NP_573462.2
1841 aa
Scn4a,  R.norvegicus
sodium channel, voltage-gated, type IV, alpha subunit
NP_037310.1
1840 aa
SCN4A,  G.gallus
sodium channel, voltage-gated, type IV, alpha subunit
XP_004948566.1
1843 aa
LOC100492371,  X.tropicalis
sodium channel protein type 4 subunit alpha-like
XP_002933087.2
1830 aa
scn4aa,  D.rerio
sodium channel, voltage-gated, type IV, alpha, a
NP_001034914.1
1829 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Paramyotonia congenita.
Hypokalemic periodic paralysis.
Hyperkalemic periodic paralysis.
Cramps, familial, potassium-aggravated.
Myasthenic syndrome.
Myotonia congenita, atypical, acetazolamide-responsive.



Publications
Articles associated with genes and sequences of this homology group.

Teaching video neuroimages: cold-induced eyelid myotonia.
Wu YJ & Lin CC. Neurology 80, e81 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Ion_trans (pfam00520)
  Ion transport protein.
Na_trans_assoc (pfam06512)
  Sodium ion transport-associated.
Na_channel_gate (cd13433)
  Inactivation gate of the voltage-gated sodium channel alpha subunits.
Ion_trans (pfam00520)
  Ion transport protein.
Na_trans_assoc (pfam06512)
  Sodium ion transport-associated.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Scn4a includes H.sapiens SCN4A and R.norvegicus Scn4a.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (22 transcripts, 7 species)
Mammalia - mammals (13 transcripts, 10 species)
Aves - birds (5 transcripts, 1 species)
Ascidiacea - tunicates (3 transcripts, 1 species)
Amphibia - amphibians (2 transcripts, 1 species)
Hyperoartia - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (16 transcripts, 10 species)
Maxillopoda - crustaceans (2 transcripts, 1 species)
Arachnida - arachnids (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (3 transcripts, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Platyhelminthes
Turbellaria - flatworms (1 transcript, 1 species)

 

 

 

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