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HomoloGene:55611. Gene conserved in Boreoeutheria Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

CR2,  H.sapiens
complement component (3d/Epstein Barr virus) receptor 2
1092 aa
CR2,  P.troglodytes
complement component (3d/Epstein Barr virus) receptor 2
1092 aa
LOC714202,  M.mulatta
complement receptor type 2-like
1161 aa
CR2,  C.lupus
complement component (3d/Epstein Barr virus) receptor 2
1089 aa
CR2,  B.taurus
complement component (3d/Epstein Barr virus) receptor 2
1472 aa
Cr2,  M.musculus
complement receptor 2
1032 aa
Cr2,  R.norvegicus
complement component (3d/Epstein Barr virus) receptor 2
1029 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

Systemic lupus erythematosus, susceptibility to, 9.

Articles associated with genes and sequences of this homology group.

CD21 positive B cell: a novel target for treatment of multiple sclerosis.
Farjam M, et al. Med Hypotheses 80, 556-7 (2013).
The role of the Epstein-Barr virus receptor CD21 in multiple sclerosis.
Toepfner N, et al. J Neuroimmunol 242, 47-51 (2012).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
CCP (cl00043)
  SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Cr2 includes H.sapiens CR2 and R.norvegicus Cr2.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (5 transcripts, 5 species)




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