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HomoloGene:20944. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

GPC3,  H.sapiens
glypican 3
NP_004475.1
580 aa
GPC3,  P.troglodytes
glypican 3
NP_001129209.1
580 aa
GPC3,  M.mulatta
glypican 3
XP_001097558.2
619 aa
GPC3,  C.lupus
glypican 3
XP_538178.2
580 aa
GPC3,  B.taurus
glypican 3
NP_001030540.1
580 aa
Gpc3,  M.musculus
glypican 3
NP_057906.2
579 aa
Gpc3,  R.norvegicus
glypican 3
NP_036906.1
597 aa
GPC3,  G.gallus
glypican 3
XP_001232892.1
576 aa
gpc3,  X.tropicalis
glypican 3
XP_002932665.2
572 aa
gpc3,  D.rerio
glypican 3
XP_688014.3
590 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Wilms tumor, somatic.
Simpson-Golabi-Behmel syndrome, type 1.



Publications
Articles associated with genes and sequences of this homology group.

Silencing glypican-3 expression induces apoptosis in human hepatocellular carcinoma cells.
Liu S, et al. Biochem Biophys Res Commun 419, 656-61 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Gpc3 includes H.sapiens GPC3 and R.norvegicus Gpc3.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (15 transcripts, 13 species)
Actinopterygii - bony fishes (2 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

 

 

 

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