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HomoloGene:9159. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

WWTR1,  H.sapiens
WW domain containing transcription regulator 1
NP_001161750.1
400 aa
WWTR1,  P.troglodytes
WW domain containing transcription regulator 1
XP_003310184.1
400 aa
WWTR1,  C.lupus
WW domain containing transcription regulator 1
XP_852547.1
400 aa
WWTR1,  B.taurus
WW domain containing transcription regulator 1
NP_001179976.1
400 aa
Wwtr1,  M.musculus
WW domain containing transcription regulator 1
NP_001161753.1
452 aa
Wwtr1,  R.norvegicus
WW domain containing transcription regulator 1
NP_001020040.1
395 aa
WWTR1,  G.gallus
WW domain containing transcription regulator 1
XP_003641834.1
386 aa
wwtr1,  X.tropicalis
WW domain containing transcription regulator 1
NP_001182698.1
390 aa
wwtr1,  D.rerio
WW domain containing transcription regulator 1
NP_001032785.1
391 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Novel mutations in the TAZ gene in patients with Barth syndrome.
Mazurov√° S, et al. Prague Med Rep 114, 139-53 (2013).
TAZ/WWTR1 is overexpressed in papillary thyroid carcinoma.
de Cristofaro T, et al. Eur J Cancer 47, 926-33 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
WW (cl00157)
  Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Wwtr1 includes H.sapiens WWTR1 and R.norvegicus Wwtr1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (12 transcripts, 9 species)
Actinopterygii - bony fishes (6 transcripts, 3 species)
Amphibia - amphibians (2 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)

Arthropoda
Insecta - insects (1 transcript, 1 species)

 

 

 

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