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HomoloGene:20917. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

CDH1,  H.sapiens
cadherin 1, type 1, E-cadherin (epithelial)
NP_004351.1
882 aa
CDH1,  P.troglodytes
cadherin 1, type 1, E-cadherin (epithelial)
XP_001168150.1
882 aa
CDH1,  M.mulatta
cadherin-1-like
XP_002802562.1
830 aa
CDH1,  C.lupus
cadherin 1, type 1, E-cadherin (epithelial)
XP_536807.3
885 aa
CDH1,  B.taurus
cadherin 1, type 1, E-cadherin (epithelial)
NP_001002763.1
882 aa
Cdh1,  M.musculus
cadherin 1
NP_033994.1
884 aa
Cdh1,  R.norvegicus
cadherin 1
NP_112624.1
886 aa
CDH1,  G.gallus
cadherin 1, type 1, E-cadherin (epithelial)
NP_001034347.2
887 aa
LOC100485633,  X.tropicalis
blastomere cadherin-like
XP_002936044.1
881 aa
cdh1,  D.rerio
cadherin 1, epithelial
NP_571895.1
864 aa
si:ch211-206i14.2,  D.rerio
si:ch211-206i14.2
XP_695998.5
809 aa
si:dkey-173l11.3,  D.rerio
si:dkey-173l11.3
XP_005166659.1
759 aa
LOC568392,  D.rerio
cadherin-1-like
XP_696808.4
719 aa
si:busm1-71b9.3,  D.rerio
si:busm1-71b9.3
XP_005166660.1
597 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Gastric cancer, familial diffuse.
Breast cancer, lobular.
Cleft lip with or without cleft palate, with gastric cancer, familial diffuse.
Endometrial carcinoma.
Listeria monocytogenes, susceptibility to.
Ovarian carcinoma.



Publications
Articles associated with genes and sequences of this homology group.

Protein O-mannosylation is crucial for E-cadherin-mediated cell adhesion.
Lommel M, et al. Proc Natl Acad Sci U S A 110, 21024-9 (2013).
E-cadherin expression in acquired cholesteatoma.
Erdoglija M, et al. B-ENT 9, 241-6 (2013).
Cadherin-dependent filopodia control preimplantation embryo compaction.
Fierro-González JC, et al. Nat Cell Biol 15, 1424-33 (2013).
The E-Cadherin expression vs. tumor cell proliferation paradox in endometrial cancer.
González-Rodilla I, et al. Anticancer Res 33, 5091-5 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Cadherin (pfam00028)
  Cadherin domain.
Cadherin_C (pfam01049)
  Cadherin cytoplasmic region.
Cadherin_pro (pfam08758)
  Cadherin prodomain like.
CA_like (cl15786)
  Cadherin repeat-like domain.
Cadherin_C (pfam01049)
  Cadherin cytoplasmic region.
Ferritin_like (cl00264)
  Ferritin-like superfamily of diiron-containing four-helix-bundle proteins.
Cadherin_pro (cl07391)
  Cadherin prodomain like.
CA_like (cl15786)
  Cadherin repeat-like domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Cdh1 includes H.sapiens CDH1 and R.norvegicus Cdh1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (13 transcripts, 11 species)
Actinopterygii - bony fishes (8 transcripts, 6 species)
Amphibia - amphibians (3 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)

 

 

 

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