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HomoloGene:48495. Gene conserved in Eukaryota Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

NOX1,  H.sapiens
NADPH oxidase 1
564 aa
NOX1,  P.troglodytes
NADPH oxidase 1
625 aa
NOX1,  M.mulatta
NADPH oxidase 1
564 aa
NOX1,  C.lupus
NADPH oxidase 1
564 aa
NOX1,  B.taurus
NADPH oxidase 1
561 aa
Nox1,  M.musculus
NADPH oxidase 1
563 aa
Nox1,  R.norvegicus
NADPH oxidase 1
563 aa
NOX1,  G.gallus
NADPH oxidase 1
561 aa
nox1,  X.tropicalis
NADPH oxidase 1
571 aa
LOC100538315,  D.rerio
cytochrome b-245 heavy chain-like
564 aa
nox1,  D.rerio
NADPH oxidase 1
576 aa
RBOH F,  A.thaliana
944 aa
Os01g0734200,  O.sativa
743 aa
Os05g0528000,  O.sativa
951 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

N-Linked glycosylation of the superoxide-producing NADPH oxidase Nox1.
Miyano K & Sumimoto H. Biochem Biophys Res Commun 443, 1060-5 (2014).
Role of type II pneumocyte senescence in radiation-induced lung fibrosis.
Citrin DE, et al. J Natl Cancer Inst 105, 1474-84 (2013).
Impaired NADPH oxidase activity in peripheral blood lymphocytes of galactosemia patients.
Al-Essa M, et al. Exp Biol Med (Maywood) 238, 779-86 (2013).
AtRbohF contributes to non-host resistance to Magnaporthe oryzae in Arabidopsis.
Nozaki M, et al. Biosci Biotechnol Biochem 77, 1323-5 (2013).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
HnRNPA1 (pfam11627)
  Nuclear factor hnRNPA1.
Ferric_reduct (pfam01794)
  Ferric reductase like transmembrane component.
EFh (cd00051)
  EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
NADPH_Ox (pfam08414)
  Respiratory burst NADPH oxidase.
Ferric_reduct (cl01043)
  This family includes a common region in the transmembrane proteins mammalian cytochrome B-245 heavy chain (gp91-phox), ferric reductase transmembrane component in yeast and respiratory burst oxidase from mouse-ear cress. This may be a family of flavocytochromes capable of moving electrons across the plasma membrane. The Frp1 protein from S. pombe is a ferric reductase component and is required for cell surface ferric reductase activity, mutants in frp1 are deficient in ferric iron uptake. Cytochrome B-245 heavy chain is a FAD-dependent dehydrogenase it is also has electron transferase activity which reduces molecular oxygen to superoxide anion, a precursor in the production of microbicidal oxidants. Mutations in the sequence of cytochrome B-245 heavy chain (gp91-phox) lead to the X-linked chronic granulomatous disease. The bacteriocidal ability of phagocytic cells is reduced and is characterized by the absence of a functional plasma membrane associated NADPH oxidase. The chronic granulomatous disease gene codes for the beta chain of cytochrome B-245 and cytochrome B-245 is missing from patients with the disease.
FNR_like (cl06868)
  Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Nox1 includes H.sapiens NOX1 and R.norvegicus Nox1.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Eudicotyledons - eudicots (47 transcripts, 26 species)
Liliopsida - monocots (18 transcripts, 9 species)
Coniferopsida - conifers (6 transcripts, 3 species)
Isoetopsida - club-mosses (5 transcripts, 1 species)
Bryopsida - mosses (2 transcripts, 1 species)

Mammalia - mammals (6 transcripts, 6 species)
Actinopterygii - bony fishes (6 transcripts, 6 species)
Aves - birds (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Arachnida - arachnids (1 transcript, 1 species)

Demospongiae - sponges (1 transcript, 1 species)

Echinoidea - sea urchins (1 transcript, 1 species)

Sordariomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Monosiga - choanoflagellates (1 transcript, 1 species)




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