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HomoloGene:1879. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

NKX2-2,  H.sapiens
NK2 homeobox 2
NP_002500.1
273 aa
NKX2-2,  P.troglodytes
NK2 homeobox 2
XP_525279.2
273 aa
NKX2-2,  M.mulatta
NK2 homeobox 2
XP_001094853.1
273 aa
NKX2-2,  C.lupus
NK2 homeobox 2
XP_542867.2
273 aa
NKX2-2,  B.taurus
NK2 homeobox 2
NP_001179638.1
273 aa
Nkx2-2,  M.musculus
NK2 homeobox 2
NP_035049.1
273 aa
Nkx2-2,  R.norvegicus
NK2 homeobox 2
NP_001178833.1
273 aa
NKX2-2,  G.gallus
NK2 homeobox 2
NP_001264647.1
272 aa
nkx2-2,  X.tropicalis
NK2 homeobox 2
XP_002939477.1
271 aa
nkx2.2a,  D.rerio
NK2 transcription factor related 2a
NP_571497.1
269 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

NKX2.2 is a useful immunohistochemical marker for Ewing sarcoma.
Yoshida A, et al. Am J Surg Pathol 36, 993-9 (2012).
Nkx2.2 regulates beta-cell function in the mature islet.
Doyle MJ & Sussel L. Diabetes 56, 1999-2007 (2007).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
homeodomain (cl00084)
  Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Nkx2-2 includes H.sapiens NKX2-2 and R.norvegicus Nkx2-2.

 

 

 

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