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HomoloGene:55430. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

CDKN2A,  H.sapiens
cyclin-dependent kinase inhibitor 2A
156 aa
CDKN2A,  P.troglodytes
cyclin-dependent kinase inhibitor 2A
156 aa
LOC709988,  M.mulatta
cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3-like
308 aa
CDKN2A,  C.lupus
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
108 aa
CDKN2A,  B.taurus
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
160 aa
Cdkn2a,  M.musculus
cyclin-dependent kinase inhibitor 2A
168 aa
Cdkn2a,  R.norvegicus
cyclin-dependent kinase inhibitor 2A
159 aa
cdkn2b,  X.tropicalis
cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
125 aa
LOC100329528,  D.rerio
cyclin-dependent kinase inhibitor 2A-like
125 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

Li Fraumeni syndrome.
Melanoma, cutaneous malignant, 2.
Melanoma and neural system tumor syndrome.
Orolaryngeal cancer, multiple.
Pancreatic cancer/melanoma syndrome.

Articles associated with genes and sequences of this homology group.

Tumor suppressor p16INK4A is necessary for survival of cervical carcinoma cell lines.
McLaughlin-Drubin ME, et al. Proc Natl Acad Sci U S A 110, 16175-80 (2013).
Immunohistochemical expression of p16 in desmoplastic melanoma.
Blokhin E, et al. J Cutan Pathol 40, 796-800 (2013).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Ank_2 (pfam12796)
  Ankyrin repeats (3 copies).
Ank_4 (pfam13637)
  Ankyrin repeats (many copies).
ANK (cd00204)
  ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
Ank_2 (pfam12796)
  Ankyrin repeats (3 copies).
Ank_4 (pfam13637)
  Ankyrin repeats (many copies).

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Cdkn2a includes H.sapiens CDKN2A and R.norvegicus Cdkn2a.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (8 transcripts, 7 species)
Actinopterygii - bony fishes (1 transcript, 1 species)




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