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HomoloGene:68719. Gene conserved in Opisthokonta Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

RAP1B,  H.sapiens
RAP1B, member of RAS oncogene family
NP_056461.1
184 aa
RAP1B,  P.troglodytes
RAP1B, member of RAS oncogene family
NP_001092015.1
184 aa
RAP1B,  M.mulatta
RAP1B, member of RAS oncogene family
XP_001117189.1
184 aa
RAP1B,  C.lupus
RAP1B, member of RAS oncogene family
XP_851250.1
184 aa
RAP1B,  B.taurus
RAP1B, member of RAS oncogene family
NP_787018.1
184 aa
Rap1b,  M.musculus
RAS related protein 1b
NP_077777.1
184 aa
Rap1b,  R.norvegicus
RAP1B, member of RAS oncogene family
NP_599173.2
184 aa
RAP1B,  G.gallus
RAP1B, member of RAS oncogene family
NP_001007853.1
184 aa
rap1b,  X.tropicalis
RAP1B, member of RAS oncogene family
NP_001008195.1
184 aa
rap1b,  D.rerio
RAS related protein 1b
NP_955827.1
184 aa
rap-1,  C.elegans
rap-1
NP_501549.1
188 aa
RSR1,  S.cerevisiae
RSR1
NP_011668.3
272 aa
KLLA0C12001g,  K.lactis
KLLA0C12001g
XP_452736.1
259 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Rap1b GTPase ameliorates glucose-induced mitochondrial dysfunction.
Sun L, et al. J Am Soc Nephrol 19, 2293-301 (2008).
Rap1b is required for normal platelet function and hemostasis in mice.
Chrzanowska-Wodnicka M, et al. J Clin Invest 115, 680-7 (2005).
cAMP-dependent oncogenic action of Rap1b in the thyroid gland.
Ribeiro-Neto F, et al. J Biol Chem 279, 46868-75 (2004).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
P-loop_NTPase (cl09099)
  P-loop containing Nucleoside Triphosphate Hydrolases.
Ras_like_GTPase (cl17170)
  Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases).



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Rap1b includes H.sapiens RAP1B and R.norvegicus Rap1b.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (22 transcripts, 17 species)
Actinopterygii - bony fishes (20 transcripts, 11 species)
Amphibia - amphibians (4 transcripts, 2 species)
Ascidiacea - tunicates (3 transcripts, 3 species)
Aves - birds (2 transcripts, 2 species)
Cephalochordata - lancelets (2 transcripts, 1 species)
Amniota - vertebrates (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (3 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (2 transcripts, 1 species)

Porifera
Demospongiae - sponges (2 transcripts, 1 species)

Arthropoda
Branchiopoda - crustaceans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (3 transcripts, 1 species)
Pezizomycetes - ascomycetes (2 transcripts, 1 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (3 transcripts, 1 species)
Liliopsida - monocots (1 transcript, 1 species)

Dictyosteliida
Dictyostelium - cellular slime molds (1 transcript, 1 species)

 

 

 

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