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HomoloGene:49516. Gene conserved in Tetrapoda Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

VPS13B,  H.sapiens
vacuolar protein sorting 13 homolog B (yeast)
NP_060360.3
4022 aa
VPS13B,  P.troglodytes
vacuolar protein sorting 13 homolog B (yeast)
XP_001151119.1
4022 aa
VPS13B,  M.mulatta
vacuolar protein sorting 13 homolog B (yeast)
XP_001096361.1
4022 aa
VPS13B,  C.lupus
vacuolar protein sorting 13 homolog B (yeast)
XP_005627877.1
4018 aa
VPS13B,  B.taurus
vacuolar protein sorting 13 homolog B (yeast)
XP_005215691.1
4017 aa
Vps13b,  M.musculus
vacuolar protein sorting 13B (yeast)
NP_796125.2
3993 aa
Vps13b,  R.norvegicus
vacuolar protein sorting 13 homolog B (yeast)
NP_001128358.1
3995 aa
VPS13B,  G.gallus
vacuolar protein sorting 13 homolog B (yeast)
XP_418354.4
4030 aa
vps13b,  X.tropicalis
vacuolar protein sorting 13 homolog B (yeast)
XP_002934455.2
4027 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Cohen syndrome.



Publications
Articles associated with genes and sequences of this homology group.

Cohen Syndrome
Wang H, et al. (1993).
Deletions in the VPS13B (COH1) gene as a cause of Cohen syndrome.
Balikova I, et al. Hum Mutat 30, E845-54 (2009).
Delineation of Cohen syndrome following a large-scale genotype-phenotype screen.
Kolehmainen J, et al. Am J Hum Genet 75, 122-7 (2004).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
ATG_C (pfam09333)
  ATG C terminal domain.
Chorein_N (pfam12624)
  N-terminal region of Chorein, a TM vesicle-mediated sorter.
DUF1162 (pfam06650)
  Protein of unknown function (DUF1162).
DUF1162 (pfam06650)
  Protein of unknown function (DUF1162).
Chorein_N (pfam12624)
  N-terminal region of Chorein, a TM vesicle-mediated sorter.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Vps13b includes H.sapiens VPS13B and R.norvegicus Cohh1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (18 transcripts, 10 species)
Actinopterygii - bony fishes (11 transcripts, 7 species)
Aves - birds (6 transcripts, 1 species)
Amniota - vertebrates (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Arthropoda
Insecta - insects (2 transcripts, 2 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

 

 

 

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