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HomoloGene:3425. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

DDX3X,  H.sapiens
DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
NP_001180345.1
661 aa
DDX3X,  C.lupus
DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
XP_005641313.1
661 aa
DDX3X,  B.taurus
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked
NP_001179891.1
661 aa
Ddx3x,  M.musculus
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, X-linked
NP_034158.1
662 aa
DDX3X,  G.gallus
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked
NP_001025971.1
651 aa
ddx3x,  X.tropicalis
DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
NP_989196.1
699 aa
bel,  D.melanogaster
belle
NP_536783.1
798 aa
laf-1,  C.elegans
laf-1
NP_001254858.1
643 aa
AT3G58510,  A.thaliana
AT3G58510
NP_001030884.1
612 aa
AT2G42520,  A.thaliana
AT2G42520
NP_181780.1
633 aa
AT3G58570,  A.thaliana
AT3G58570
NP_191416.1
646 aa
Os07g0202100,  O.sativa
Os07g0202100
NP_001059135.1
638 aa
Os03g0805200,  O.sativa
Os03g0805200
NP_001051626.1
637 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Viruses and the human DEAD-box helicase DDX3: inhibition or exploitation?
Schröder M. Biochem Soc Trans 39, 679-83 (2011).
The role of DDX3 in regulating Snail.
Sun M, et al. Biochim Biophys Acta 1813, 438-47 (2011).
Identification of an antiapoptotic protein complex at death receptors.
Sun M, et al. Cell Death Differ 15, 1887-900 (2008).
Oncogenic role of DDX3 in breast cancer biogenesis.
Botlagunta M, et al. Oncogene 27, 3912-22 (2008).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
HELICc (cd00079)
  Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
eIF-4B (pfam06273)
  Plant specific eukaryotic initiation factor 4B.
DEXDc (cl17251)
  DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Ddx3x includes H.sapiens DDX3X and R.norvegicus Ddx3x.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Streptophyta
Eudicotyledons - eudicots (83 transcripts, 32 species)
Liliopsida - monocots (19 transcripts, 8 species)
Coniferopsida - conifers (6 transcripts, 3 species)
Bryopsida - mosses (5 transcripts, 1 species)
Isoetopsida - club-mosses (3 transcripts, 1 species)

Chlorophyta
Chlorophyceae - green algae (2 transcripts, 2 species)

Chordata
Actinopterygii - bony fishes (19 transcripts, 10 species)
Mammalia - mammals (17 transcripts, 12 species)
Amphibia - amphibians (4 transcripts, 2 species)
Ascidiacea - tunicates (3 transcripts, 2 species)
Aves - birds (3 transcripts, 3 species)
Cephalochordata - lancelets (2 transcripts, 1 species)
Hyperoartia - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (13 transcripts, 11 species)
Arachnida - arachnids (2 transcripts, 2 species)
Malacostraca - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (5 transcripts, 2 species)
Turbellaria - flatworms (5 transcripts, 1 species)

Cnidaria
Hydrozoa - hydrozoans (3 transcripts, 2 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (4 transcripts, 2 species)

Annelida
Hirudinida - segmented worms (3 transcripts, 1 species)
Polychaeta - segmented worms (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (2 transcripts, 2 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 2 species)

Apicomplexa
Coccidia - apicomplexans (2 transcripts, 1 species)

Dictyosteliida
Dictyostelium - cellular slime molds (1 transcript, 1 species)

 

 

 

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