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HomoloGene:31141. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

TERT,  H.sapiens
telomerase reverse transcriptase
1132 aa
TERT,  P.troglodytes
telomerase reverse transcriptase
1135 aa
TERT,  C.lupus
telomerase reverse transcriptase
1123 aa
TERT,  B.taurus
telomerase reverse transcriptase
1125 aa
Tert,  M.musculus
telomerase reverse transcriptase
1122 aa
Tert,  R.norvegicus
telomerase reverse transcriptase
1125 aa
TERT,  G.gallus
telomerase reverse transcriptase
1346 aa
tert,  X.tropicalis
telomerase reverse transcriptase
1214 aa
tert,  D.rerio
telomerase reverse transcriptase
1098 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

Aplastic anemia, susceptibility to.

Articles associated with genes and sequences of this homology group.

Pulmonary alveolar proteinosis revealing a telomerase disease.
Marchand-Adam S, et al. Am J Respir Crit Care Med 188, 402-4 (2013).
Frequency of TERT promoter mutations in human cancers.
Vinagre J, et al. Nat Commun 4, 2185 (2013).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
RVT_1 (pfam00078)
  Reverse transcriptase (RNA-dependent DNA polymerase).
RT_like (cl02808)
  RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons, ...
Telomerase_RBD (cl13446)
  Telomeres in most organisms are comprised of tandem simple sequence repeats. The total length of telomeric repeat sequence at each chromosome end is determined in a balance of sequence loss and sequence addition. One major influence on telomere length is the enzyme telomerase. It is a reverse transcriptase that adds these simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. The RNA binding domain of telomerase - TRBD - is made up of twelve alpha helices and two short beta sheets. How telomerase and associated regulatory factors physically interact and function with each other to maintain appropriate telomere length is poorly understood. It is known however that TRBD is involved in formation of the holoenzyme (which performs the telomere extension) in addition to recognition and binding of RNA.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Tert includes H.sapiens TERT and R.norvegicus Tert.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (6 transcripts, 6 species)
Actinopterygii - bony fishes (2 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)

Liliopsida - monocots (3 transcripts, 3 species)
Eudicotyledons - eudicots (2 transcripts, 2 species)




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