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HomoloGene:20123. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

EGR2,  H.sapiens
early growth response 2
NP_000390.2
476 aa
EGR2,  P.troglodytes
early growth response 2
XP_001165924.2
476 aa
EGR2,  M.mulatta
early growth response 2
XP_001092603.2
489 aa
EGR2,  C.lupus
early growth response 2
XP_536361.3
485 aa
EGR2,  B.taurus
early growth response 2
XP_002698898.1
485 aa
Egr2,  M.musculus
early growth response 2
NP_034248.2
470 aa
Egr2,  R.norvegicus
early growth response 2
NP_446085.1
470 aa
egr2,  X.tropicalis
early growth response 2 (Krox-20 homolog)
NP_001093725.1
429 aa
egr2b,  D.rerio
early growth response 2b
NP_571072.2
412 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Dejerine-Sottas neuropathy.
Neuropathy, congenital hypomyelinating, 1.
Charcot-Marie-Tooth disease, type 1D.



Publications
Articles associated with genes and sequences of this homology group.

Egr2-neurons control the adult respiratory response to hypercapnia.
Ray RS, et al. Brain Res 1511, 115-25 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
DUF3446 (pfam11928)
  Domain of unknown function (DUF3446).
zf-H2C2_2 (pfam13465)
  Zinc-finger double domain.
zf-C2H2 (cl15478)
  Zinc finger, C2H2 type.
zf-C2H2 (pfam00096)
  Zinc finger, C2H2 type.
DUF3446 (pfam11928)
  Domain of unknown function (DUF3446).
zf-H2C2_2 (cl19539)
  Zinc-finger double domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Egr2 includes H.sapiens EGR2 and R.norvegicus Egr2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (11 transcripts, 9 species)
Actinopterygii - bony fishes (6 transcripts, 5 species)
Amphibia - amphibians (2 transcripts, 2 species)

Platyhelminthes
Turbellaria - flatworms (2 transcripts, 1 species)

Arthropoda
Insecta - insects (1 transcript, 1 species)

 

 

 

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